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ClinicalChemistry55:2Introduction201–202(2009)High-SensitivityC-ReactiveProteinandCardiovascularDiseaseConsideringhowmuchattentionhasbeenpaidtodis-WiththeincreasedinterestintheutilityofhsCRPeasesoftheheartduringthepasttwentyyears,theirhis-incardiovasculardiseaseriskassessment,thenumbertoryandcausesmightbymostpersonsberegardedasofhsCRPmeasurementsperformedinlaboratoriesinnearlycomplete.theUShasbeenrisingoverthepastfewyears(Fig.1).—GeorgeBurrows,FRSAAsaresultofthefindingsfromJUPITER,weanticipateFebruary23,1847anevengreaterincreaseinhsCRPtestingintheUSandelsewhere.OnNovember9,2008,thedaythedatafromAcenturyandahalfaftertheproclamationofBorrows,JUPITERwerepresentedandthefindingsfrom2piv-thesearchforamarkerofcoronaryheartdiseasecon-otalhsCRPstudiesfromthePhysicians’HealthStudytinues;morethan60%ofthosewhodevelopcoronaryandtheFraminghamHeartOffspringStudywerepub-eventshaveonlyone,orevennoneofthetraditionallished,ElizabethG.Nabel,directoroftheNationalriskfactors,andmorethanhalfhaveeithernormalorHeart,LungandBloodInstitute,releasedastatementmildlyincreasedlipidvalues.Becauseoftheunex-ontheroleofinflammationandhsCRPincardiovas-pectedearlyterminationandrecentreleaseofthepos-culardisease.Nabelconcludedthat“Together,theseitivefindingsoftheJustificationfortheUseofStatinsstudiesshowgreatpromiseinhelpingcliniciansbetterinPrimaryPrevention:anInterventionTrialEvaluat-identifyandtreatindividualsatriskforcardiovascularingRosuvastatin(JUPITER3;ClinicalTrials.govnum-disease-potentiallysavingmillionsmorelives.”TheseberNCT00239681),thisissueofClinicalChemistryisdevelopmentscreatealargerroleforclinicalchemistsdevotedtoC-reactiveprotein(CRP)research.Webe-inthisendeavor,throughimplementingappropriatelievethatJUPITERisalandmarktrialinpreventivemethods,providingcorrectinterpretations,andsup-cardiologyandoneofthemostsignificantdevelop-portingclinicians.Unfortunately,2commonprob-mentsinthisfieldsincetheinceptionoftheNationallemsinthemeasurementofhsCRPandthereportingCho
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