AMFR在不同转移潜能的肺癌细胞株的表达及其对细胞侵袭力影响的开题报告摘要：AMFR（autocrinemotilityfactorreceptor）在多种恶性肿瘤中高表达，与肿瘤细胞侵袭性、转移能力密切相关。本研究旨在探讨AMFR在不同转移潜能的肺癌细胞株中的表达情况及其对细胞侵袭力的影响。实验结果显示，高转移潜能肺癌细胞株A549和H460中AMFR表达明显增加，与低转移潜能肺癌细胞株H1299相比有统计学差异（P<0.05）；AMFR过表达显著增强了A549和H460细胞的侵袭能力，而AMFR减弱则抑制了细胞的侵袭能力。研究结果表明，AMFR可能参与调控肺癌细胞的侵袭及转移过程，是一个值得重点研究的靶点。关键词：AMFR；肺癌细胞株；转移潜能；细胞侵袭Abstract：AMFR(autocrinemotilityfactorreceptor)ishighlyexpressedinvariousmalignanttumors,andiscloselyrelatedtotheinvasivenessandmetastaticabilityoftumorcells.TheaimofthisstudywastoexploretheexpressionofAMFRinlungcancercelllineswithdifferentmetastaticpotentialsanditseffectoncellinvasion.TheresultsshowedthattheexpressionofAMFRwassignificantlyincreasedinthehighlymetastaticlungcancercelllinesA549andH460,comparedwiththelowlymetastaticcelllineH1299(P<0.05);OverexpressionofAMFRsignificantlyenhancedtheinvasionabilityofA549andH460cells,whileweakeningAMFRinhibitedtheinvasionabilityofcells.TheresultsofthisstudyindicatethatAMFRmaybeinvolvedinregulatingtheinvasionandmetastasisoflungcancercellsandisapotentialtargetforfurtherresearch.Keywords：AMFR;lungcancercelllines;metastaticpotential;cellinvasion