黄芪扶正汤抑制Lewis肺癌移植瘤生长及其机制的实验研究的开题报告【摘要】黄芪扶正汤以黄芪、白术、人参为主要配方，常用于中医药治疗疲劳、虚弱和身体虚弱等症状。本研究旨在评估黄芪扶正汤对Lewis肺癌移植瘤生长的影响，并探讨其作用机制。本研究将Lewis肺癌细胞移植入小鼠体内，制成Lewis肺癌移植瘤模型。然后，将小鼠分为治疗组和对照组，治疗组给予黄芪扶正汤，对照组给予生理盐水。观察生长瘤的大小并记录并分析肺癌细胞密度、肿瘤生长指数和生存率。此外，还将分析黄芪扶正汤对瘤内的炎性细胞和免疫细胞浸润的影响。本研究的目的在于确定黄芪扶正汤是否可以作为潜在的治疗肺癌的中药方剂，以及探究其药理作用机制。【关键词】黄芪扶正汤、Lewis肺癌、移植瘤、炎性细胞、免疫细胞【Abstract】HuangqiFuzhengTang,whichconsistsofRadixAstragali,RhizomaAtractylodisMacrocephalae,andRadixGinseng,isatraditionalChinesemedicineformulacommonlyusedfortreatingfatigue,weakness,andphysicaldebility.ThisstudyaimstoevaluatetheeffectsofHuangqiFuzhengTangonthegrowthofLewislungcarcinoma(LLC)tumorsandtoexploreitsunderlyingmechanisms.LLCcellswereimplantedintomicetoestablishtheLLCtumormodel.Miceweredividedintotreatmentandcontrolgroups,withthetreatmentgroupreceivingHuangqiFuzhengTangandthecontrolgroupreceivingsaline.Tumorsizewasmeasured,andthedensityofLLCcells,tumorgrowthindex,andsurvivalratewereanalyzed.Inaddition,theeffectofHuangqiFuzhengTangoninflammatorycellsandimmunecellsinfiltratingthetumorwasexamined.ThepurposeofthisstudyistodeterminewhetherHuangqiFuzhengTangcanbeapotentialChineseherbalformulaforthetreatmentoflungcancerandtoexploreitspharmacologicalmechanisms.【Keywords】HuangqiFuzhengTang,Lewislungcarcinoma,implantationtumor,inflammatorycells,immunecells