SIRT1在子宫内膜样腺癌中的表达的开题报告Title:TheExpressionofSIRT1inEndometrioidAdenocarcinomaIntroduction:Endometrioidadenocarcinomaisatypeofcancerthatoccursintheliningoftheuterus.Itisthemostcommontypeofendometrialcancerandaccountsforabout80%ofcases.SIRT1isaproteinthatisinvolvedinvariouscellularprocessesincludingDNArepair,apoptosis,andaging.SIRT1hasbeenshowntoplayaroleinthedevelopmentofseveraltypesofcancerincludingbreast,prostate,andcoloncancer.However,itsroleinendometrialcancerisnotfullyunderstood.Objective:TheobjectiveofthisstudyistoinvestigatetheexpressionofSIRT1inendometrioidadenocarcinomaanddetermineitspotentialroleinthedevelopmentandprogressionofthiscancer.Methods:TissuesamplesfrompatientsdiagnosedwithendometrioidadenocarcinomawillbecollectedandanalyzedfortheexpressionofSIRT1usingimmunohistochemistry.TheexpressionlevelsofSIRT1willbecomparedtonormalendometrialtissuesamples.ThecorrelationbetweenSIRT1expressionandclinicopathologicalfactorssuchastumorstage,grade,andpatientsurvivalwillalsobeanalyzed.ExpectedResults:ItisexpectedthatSIRT1expressionwillbeupregulatedinendometrioidadenocarcinomacomparedtonormalendometrialtissues.HigherexpressionlevelsofSIRT1mayalsobeassociatedwithmoreadvancedtumorstageandpoorerpatientsurvival.Conclusion:ThisstudywillprovideinsightintotheroleofSIRT1inendometrioidadenocarcinomaanditspotentialasatargetfortherapeuticintervention.Understandingthemolecularmechanismsinvolvedinthedevelopmentandprogressionofendometrialcancercanhelpimprovediagnosisandtreatmentoutcomesforpatients.