NM23、Survivin在大肠癌组织中的表达与临床意义的开题报告摘要背景：大肠癌是最常见的消化系统肿瘤之一，早期诊断和治疗对改善患者预后至关重要。NM23和Survivin是与肿瘤发生、发展密切相关的分子，其在大肠癌中的表达与患者预后关系尚不清楚。目的：本研究旨在探究NM23和Survivin在大肠癌组织中的表达及其与临床病理特征和预后的关系，为大肠癌的诊治提供参考。方法：采用免疫组化技术检测大肠癌患者组织NM23和Survivin的表达情况，并与患者临床病理特征及预后进行相关分析。预期结果：本研究预计能够从分子水平上探究NM23和Survivin在大肠癌中的作用机制，为大肠癌的诊治提供新的分子靶点和治疗方法。结论：NM23和Survivin在大肠癌组织中的表达与患者预后密切相关，具有重要的临床意义，可能成为预测和治疗大肠癌的有力工具。关键词：NM23；Survivin；大肠癌；免疫组化技术；预后AbstractBackground:Colorectalcancerisoneofthemostcommondigestivesystemtumors,earlydiagnosisandtreatmentarecrucialforimprovingtheprognosisofpatients.NM23andSurvivinaremoleculescloselyrelatedtotumoroccurrenceanddevelopment.Theirexpressionincolorectalcancerandtherelationshipwithpatientprognosisarestillunclear.Objective:ThisstudyaimstoexploretheexpressionofNM23andSurvivinincolorectalcancertissuesandtheirrelationshipwithclinicalpathologicalfeaturesandprognosis,providingreferenceforthediagnosisandtreatmentofcolorectalcancer.Methods:ImmunohistochemicaltechniquewasusedtodetecttheexpressionofNM23andSurvivinincolorectalcancertissues,andtheircorrelationwithclinicalpathologicalfeaturesandprognosiswasanalyzed.Expectedresults:ThisstudyisexpectedtoexploretheroleofNM23andSurvivinincolorectalcanceratthemolecularlevel,providingnewmoleculartargetsandtreatmentmethodsforthediagnosisandtreatmentofcolorectalcancer.Conclusion:TheexpressionofNM23andSurvivinincolorectalcancertissuesiscloselyrelatedtopatientprognosisandhasimportantclinicalsignificance.Theymaybecomepowerfultoolsforpredictingandtreatingcolorectalcancer.Keywords:NM23;Survivin;Colorectalcancer;Immunohistochemicaltechnique;Prognosis