抗肿瘤物质筛选模型的建立及其应用的综述报告-第一文库 | 海量文档资源下载与分享平台

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抗肿瘤物质筛选模型的建立及其应用的综述报告Abstract：Cancerisamajorthreattohumanhealth.Thedevelopmentofanti-tumorsubstanceshasalwaysbeenoneofthehotspotsinthefieldofpharmaceuticalresearch.Inordertodiscovermoreeffectiveandspecificanti-tumordrugs,itisnecessarytoestablishareliablemodelforscreeninganti-tumorsubstances.Inthisarticle,wewillreviewtheestablishmentandapplicationofavarietyofanti-tumorsubstancescreeningmodels,includinginvitro,invivo,andcomputationalsimulations.Thesemodelshavemadegreatcontributionstothediscoveryanddevelopmentofanti-tumordrugs.Keywords:anti-tumorsubstances,screeningmodel,invitro,invivo,computationalsimulationIntroduction：Cancerhasbecomeoneofthemajorthreatstohumanhealth.Althoughsignificantprogresshasbeenmadeinthediagnosisandtreatmentofcancerinrecentyears,thereisstillalongwaytogotodiscovertrulyeffectiveandtargetedanti-tumoragents.Thedevelopmentofanti-tumordrugsrequiresareliablescreeningmodeltoidentifypotentialcompounds.Theestablishmentofascreeningmodelforanti-tumorsubstancesisofgreatsignificancetothediscoveryofeffectivedrugs.Invitro,invivo,andcomputationalsimulationmethodshavebeenwidelyusedtoestablishdifferentanti-tumorsubstancescreeningmodels.Eachmodelhasitsownadvantagesandlimitations.Invitroscreeningmodels：Invitroscreeningmodelsrefertotheuseofcellculturesystemstoevaluatethetoxicityandeffectivenessofanti-tumoragents.Avarietyofcelllineshavebeenusedtoestablishinvitroscreeningmodels,suchashumantumorcelllinesandanimalcelllines.Thesemodelsallowfortheassessmentofcellproliferation,cellcycle,apoptosis,andotherimportantparameterstodeterminethepotentialeffectivenessofdrugs.Oneexampleofaninvitroscreeningmodelisthehigh-throughputscreening(HTS)method.Thismethodcanscreenhundredsofthousandsofcompoundsinamatterofdaysandidentifyleadcompoundsforfurtherevaluation.Anotherexampleisthethree-dimensional(3D)cellculturemodel,whichmimicsthestructureandfunctionoftumorsmorecloselythantraditionaltwo-dimensional(2D)cellcultures.Invivoscreeningmodels：Invivoscreeningmodelsarebasedontheuseof