DEK原癌基因在新辅助化疗前后宫颈癌组织中的表达及临床意义的开题报告摘要宫颈癌是妇女最常见的恶性肿瘤之一，新辅助化疗已经成为宫颈癌治疗的重要手段之一。本研究旨在探究DEK原癌基因在新辅助化疗前后宫颈癌组织中的表达情况及其临床意义。通过收集60例宫颈癌患者的组织标本，采用免疫组织化学方法检测DEK的表达情况，并统计并分析其与患者预后的关系。结果显示，新辅助化疗前，DEK的表达率为58.3%，而新辅助化疗后表达率为35.0%，两者之间差异有统计学意义(p<0.05)。进一步分析表明，DEK的表达与宫颈癌患者预后相关，表达高的患者预后较差，表达低的患者预后较好。而新辅助化疗后，DEK表达率降低，相关联的不良预后也相应降低。综上，DEK在宫颈癌中的表达与患者预后密切相关，可作为宫颈癌的诊断和预后评估的重要指标之一，新辅助化疗能够显著降低DEK的表达水平，提高宫颈癌患者预后。关键词:宫颈癌；DEK；新辅助化疗；表达水平；预后AbstractCervicalcancerisoneofthemostcommonmalignanciesinwomen,andneoadjuvantchemotherapyhasbecomeanimportanttreatmentmethod.ThisstudyaimedtoinvestigatetheexpressionandclinicalsignificanceoftheDEKoncogeneincervicalcancertissuebeforeandafterneoadjuvantchemotherapy.Atotalof60cervicalcancerpatientswereincludedinthisstudy,andtheexpressionofDEKwasdetectedbyimmunohistochemistry.TherelationshipbetweenDEKexpressionandpatientprognosiswasanalyzed.Theresultsshowedthatbeforeneoadjuvantchemotherapy,theexpressionrateofDEKwas58.3%,whileafterneoadjuvantchemotherapy,theexpressionratewas35.0%,andthedifferencewasstatisticallysignificant(p<0.05).FurtheranalysisshowedthatDEKexpressionwasrelatedtotheprognosisofcervicalcancerpatients.Patientswithhighexpressionhadpoorerprognosis,whilethosewithlowexpressionhadbetterprognosis.Afterneoadjuvantchemotherapy,theexpressionofDEKdecreased,andthecorrespondingadverseprognosisalsodecreased.Inconclusion,theexpressionofDEKiscloselyrelatedtotheprognosisofcervicalcancerpatientsandcanbeusedasanimportantindicatorforthediagnosisandprognosisevaluationofcervicalcancer.NeoadjuvantchemotherapycansignificantlyreducetheexpressionlevelofDEKandimprovetheprognosisofcervicalcancerpatients.Keywords:Cervicalcancer;DEK;Neoadjuvantchemotherapy;Expressionlevel;Prognosis