纤维蛋白原FGA-128C/G基因多态性与脑梗死的相关性研究的开题报告摘要在中国，脑梗死是一种严重的心血管疾病，其发病率和死亡率居高不下。先前的研究表明，纤维蛋白原（Fibrinogen）是血小板及血络瘤形成过程中的一个重要因素，并且与心血管疾病和脑梗死的发生有着密切关系。本研究旨在探讨纤维蛋白原FGA-128C/G基因多态性与脑梗死的相关性。方法收集200例脑梗死患者和200名健康的对照组成的样本，采用PCR-RFLP技术分析FGA-128C/G基因多态性，并比较两组的基因型分布情况和等位基因频率。预期结果预计将发现脑梗死患者中FGA-128G等位基因频率较高，且与脑梗死的发生有关，与此同时，FGA-128GG基因型携带者的风险将高于CC基因型携带者。本研究有助于进一步认识FGA-128C/G基因多态性与脑梗死的相关性，增强对脑梗死的预测和预防。关键词：纤维蛋白原、FGA-128C/G基因多态性、脑梗死、PCR-RFLP技术、基因型分析AbstractInChina,cerebralinfarctionisaseriouscardiovasculardiseasewithhighincidenceandmortality.Previousstudieshaveshownthatfibrinogenisanimportantfactorinplateletandthrombusformationandiscloselyrelatedtotheoccurrenceofcardiovasculardiseaseandcerebralinfarction.ThisstudyaimstoexplorethecorrelationbetweenfibrinogenFGA-128C/Ggenepolymorphismandcerebralinfarction.MethodsTwohundredpatientswithcerebralinfarctionand200healthycontrolswerecollected.PCR-RFLPtechnologywasusedtoanalyzeFGA-128C/Ggenepolymorphism,andthegenotypedistributionandallelefrequencyofthetwogroupswerecompared.ExpectedresultsItisexpectedthatthefrequencyofFGA-128Gallelewillbehigherinpatientswithcerebralinfarction,anditwillberelatedtotheoccurrenceofcerebralinfarction.Atthesametime,theriskofFGA-128GGgenotypecarrierswillbehigherthanthatofCCgenotypecarriers.ThisstudywillhelptofurtherunderstandthecorrelationbetweenFGA-128C/Ggenepolymorphismandcerebralinfarction,andenhancethepredictionandpreventionofcerebralinfarction.Keywords:fibrinogen,FGA-128C/Ggenepolymorphism,cerebralinfarction,PCR-RFLPtechnology,genotypeanalysis