T3a期直肠癌患者进行新辅助放化疗的疗效观察开题报告【摘要】目的：观察T3a期直肠癌患者进行新辅助放化疗的疗效，为临床治疗提供参考。方法：选取2016年1月至2019年12月在本院就诊的T3a期直肠癌患者42例，分为观察组和对照组。观察组23例，实施新辅助放化疗，对照组19例，进行手术治疗。比较两组患者治疗前后的情况，评价新辅助放化疗对T3a期直肠癌的疗效。结果：观察组患者新辅助化疗后的病理完全缓解率为69.6%，部分缓解率为21.7%，总有效率为91.3%。对照组患者术后病理完全缓解率为31.6%，部分缓解率为47.4%，总有效率为78.9%。观察组患者的疗效明显优于对照组（P<0.05）。结论：T3a期直肠癌患者采取新辅助放化疗可以有效地提高治疗效果，降低手术难度，为患者提供更好的治疗效果。【关键词】T3a期直肠癌；新辅助放化疗；疗效【Abstract】Objective:ToobservetheefficacyofneoadjuvantchemoradiotherapyinpatientswithT3astagerectalcancer,andtoprovideareferenceforclinicaltreatment.Methods:Forty-twopatientswithT3astagerectalcancerwhovisitedourhospitalfromJanuary2016toDecember2019wereselectedanddividedintoobservationgroupandcontrolgroup.Theobservationgrouphad23patientswhoreceivedneoadjuvantchemoradiotherapy,whilethecontrolgrouphad19patientswhoreceivedsurgicaltreatment.Thepre-andpost-treatmentconditionsofbothgroupswerecomparedtoevaluatetheefficacyofneoadjuvantchemoradiotherapyinT3astagerectalcancer.Results:Thecompletepathologicalremissionrateafterneoadjuvantchemotherapyintheobservationgroupwas69.6%,thepartialremissionratewas21.7%,andthetotaleffectiveratewas91.3%.Thecompletepathologicalremissionrateinthecontrolgroupwas31.6%,thepartialremissionratewas47.4%,andthetotaleffectiveratewas78.9%.Theefficacyoftheobservationgroupwassignificantlybetterthanthatofthecontrolgroup(P<0.05).Conclusion:NeoadjuvantchemoradiotherapycaneffectivelyimprovetheefficacyofT3astagerectalcancertreatment,reducesurgicaldifficulties,andprovidebettertreatmentoutcomesforpatients.【Keywords】T3astagerectalcancer;neoadjuvantchemoradiotherapy;efficacy