RECK和MMp-2在皮肤鳞状细胞癌中的表达及临床意义的开题报告摘要：皮肤鳞状细胞癌是一种常见的肿瘤，近年来发病率不断上升。RECK和MMp-2是该肿瘤发生、发展中的重要因素，本研究旨在探讨RECK和MMp-2在皮肤鳞状细胞癌中的表达及其临床意义。采用免疫组织化学法检测皮肤鳞状细胞癌组织和正常皮肤组织中RECK和MMp-2的表达情况，并分析二者之间的关系及其与临床病情相关性。结果显示，皮肤鳞状细胞癌组织中RECK的表达显著降低，而MMp-2的表达升高，表明RECK和MMp-2在该肿瘤中发挥着相反的作用。此外，RECK和MMp-2的表达与皮肤鳞状细胞癌的分化程度、浸润深度及转移情况等临床病理指标密切相关，提示RECK和MMp-2可能作为皮肤鳞状细胞癌的诊断和治疗指标。关键词：皮肤鳞状细胞癌；RECK；MMp-2；免疫组织化学Abstract:Squamouscellcarcinoma(SCC)isacommontumorintheskin,anditsincidencehasbeenincreasinginrecentyears.RECKandMMp-2areimportantfactorsintheoccurrenceanddevelopmentofthistumor.ThisstudyaimedtoinvestigatetheexpressionandclinicalsignificanceofRECKandMMp-2inSCC.ImmunohistochemistrywasusedtodetecttheexpressionofRECKandMMp-2inSCCtissuesandnormalskintissues,andtherelationshipbetweenthetwowasanalyzed,aswellastheircorrelationwithclinicalconditions.TheresultsshowedthattheexpressionofRECKwassignificantlydecreasedinSCCtissues,whiletheexpressionofMMp-2wasincreased,indicatingthatRECKandMMp-2playedoppositerolesinthistumor.Inaddition,theexpressionofRECKandMMp-2wascloselyrelatedtoclinicalpathologicalindicatorssuchasthedegreeofdifferentiation,infiltrationdepth,andmetastasisofSCC,suggestingthatRECKandMMp-2maybeusedasdiagnosticandtherapeuticindicatorsforSCC.Keywords:squamouscellcarcinoma;RECK;MMp-2;immunohistochemistry.