上皮性卵巢癌DNA异常甲基化模式及其在分子分型和临床诊断中应用的研究的开题报告摘要上皮性卵巢癌是女性最常见的恶性肿瘤之一，其发生、发展涉及复杂的致癌机制，其中DNA甲基化异常是近年来备受关注的一个方面。本文旨在探讨上皮性卵巢癌中DNA异常甲基化模式的分子机制，尤其是在分子分型和临床诊断中的应用。首先，本文将回顾上皮性卵巢癌的相关背景及其分子分型，重点介绍已有的DNA甲基化研究进展和最新的技术手段。随后，本文将阐述上皮性卵巢癌中DNA甲基化在分子分型中的应用，包括P53突变型、BRCA1/2突变型、CpG岛甲基化型等，同时强调其在分子分型中的优越性和应用前景。最后，本文将重点讨论上皮性卵巢癌中DNA异常甲基化模式在临床诊断中的应用，探讨其在早期诊断、预后判断、治疗监测等方面的应用前景，以期为上皮性卵巢癌的诊断和治疗提供新的方向和思路。关键词：上皮性卵巢癌；DNA异常甲基化；分子分型；临床诊断AbstractEpithelialovariancancerisoneofthemostcommonmalignanttumorsinwomen,anditsoccurrenceanddevelopmentinvolvecomplexcarcinogenicmechanisms,amongwhichDNAmethylationabnormalitieshavebeenafocusofattentioninrecentyears.ThisarticleaimstoexplorethemolecularmechanismofDNAabnormalmethylationpatterninepithelialovariancancer,especiallyitsapplicationinmolecularsubtypingandclinicaldiagnosis.Firstly,thisarticlewillreviewtherelevantbackgroundofepithelialovariancanceranditsmolecularsubtyping,andintroducetheexistingresearchprogressofDNAmethylationandthelatesttechnicalmeans.Then,thisarticlewillexplaintheapplicationofDNAmethylationinmolecularsubtypingofepithelialovariancancer,includingP53mutationtype,BRCA1/2mutationtype,CpGislandmethylationtype,andemphasizeitssuperiorityandapplicationprospectinmolecularsubtyping.Finally,thisarticlewillfocusontheapplicationofDNAabnormalmethylationpatterninclinicaldiagnosisofepithelialovariancancer,discussingitsapplicationprospectinearlydiagnosis,prognosisjudgment,treatmentmonitoring,etc.,inordertoprovidenewdirectionsandideasforthediagnosisandtreatmentofepithelialovariancancer.Keywords:Epithelialovariancancer;DNAabnormalmethylation;Molecularsubtyping;Clinicaldiagnosis