NOD1在肥胖糖尿病患者脂肪细胞中的表达及对胰岛素抵抗的作用的开题报告摘要：肥胖糖尿病是一种慢性代谢紊乱疾病，其发生发展与多种生理和病理因素密切相关。NOD样受体1（NOD1）被认为是一种参与慢性炎症及胰岛素抵抗的重要因素。本文旨在研究NOD1在肥胖糖尿病患者脂肪细胞中的表达情况，并探究其对胰岛素抵抗的作用。文中将会介绍NOD1的缺陷对胰岛素抵抗的保护作用、NOD1与炎症因子的关系以及NOD1在肥胖糖尿病患者脂肪细胞中的表达情况。此外，本文还将探讨NOD1如何通过调节IL-6的表达对胰岛素抵抗产生影响。最后，本文将总结NOD1在肥胖糖尿病中的作用，为研究肥胖糖尿病的治疗提供理论依据。关键词：NOD1、肥胖糖尿病、脂肪细胞、胰岛素抵抗、IL-6Abstract:Obesityanddiabetesarechronicmetabolicdisorders,andtheiroccurrenceanddevelopmentarecloselyrelatedtovariousphysiologicalandpathologicalfactors.NOD-likereceptor1(NOD1)isconsideredasanimportantfactorinvolvedinchronicinflammationandinsulinresistance.ThisthesisaimstostudytheexpressionofNOD1inadipocytesofobesediabeticpatientsandexploreitseffectoninsulinresistance.ThispaperwillintroducetheprotectiveeffectofNOD1defectsoninsulinresistance,therelationshipbetweenNOD1andinflammatoryfactors,andtheexpressionofNOD1inadipocytesofobesediabeticpatients.Inaddition,thispaperwillexplorehowNOD1affectsinsulinresistancebyregulatingtheexpressionofIL-6.Finally,thispaperwillsummarizetheroleofNOD1inobesityanddiabetes,andprovidetheoreticalbasisforthetreatmentofobesityanddiabetes.Keywords:NOD1,obesity,diabetes,adipocytes,insulinresistance,IL-6