含生物可降解聚酯、聚氨基酸嵌段共聚物的合成与性能研究的中期报告Introduction概述Environmentalpollutioncausedbynon-biodegradablepolymershasbecomeamajorchallengetosustainabledevelopment.Asaresult,thereisanurgentneedforthedevelopmentofsustainable,biodegradablepolymers.Biodegradablepolyestershaveattractedsignificantattentionbecauseoftheirexcellentbiodegradabilityandbiocompatibility.However,theirphysicalandmechanicalpropertiesneedtobeimprovedtomeetpracticalrequirements.Inthisstudy,weproposedanovelapproachtoenhancethephysicalandmechanicalpropertiesofbiodegradablepolyestersbyincorporatingpolyaminoacidblockcopolymersintothepolyestermatrix.非可降解聚合物造成的环境污染已成为可持续发展的主要挑战。因此，开发可持续、可降解的聚合物迫在眉睫。由于其优异的降解性和生物相容性，生物可降解聚酯备受关注。然而，它们的物理和机械性能需要改进以满足实际需求。在本研究中，我们提出了一种新方法，通过将聚氨基酸嵌段共聚物引入聚酯基体中，来增强其物理和机械性能。Methods方法Poly(L-lactide-co-glycolide)(PLGA)wassynthesizedbyring-openingpolymerizationofL-lactideandglycolideinthepresenceofstannousoctoateasacatalyst.Poly(L-lactide-co-glycolide)-b-poly(γ-benzyl-L-glutamate)(PLGA-PBLG)blockcopolymerswerepreparedbythering-openingpolymerizationofγ-benzyl-L-glutamateN-carboxyanhydrideinthepresenceofPLGAasamacroinitiator.ThePLGAandPLGA-PBLGcopolymerswerecharacterizedbyNMRandGPC.在辛酸亚锡的催化下，通过L-乳酸和乙二醇酸的环开聚合合成聚（L-乳酸-共-乙二醇酸）（PLGA）。通过γ-对苯甲酰基-L-谷氨酸-N-羧酸酐的环开聚合，在PLGA作为巨大初始剂的存在下合成了嵌段共聚物聚（L-乳酸-共-乙二醇酸）-b-聚（γ-苯甲酰-L-谷氨酸）（PLGA-PBLG）。通过NMR和GPC进行了PLGA和PLGA-PBLG嵌段共聚物的表征。ResultsandDiscussion结果与讨论ThemolecularweightandcompositionofthePLGAandPLGA-PBLGcopolymerswereanalyzedbyGPCandNMR.Thecopolymerblocklengthswerevariedtoinvestigatetheireffectsonthephysicalandmechanicalpropertiesofthematerials.TheresultsshowedthatthemechanicalpropertiesofthematerialsweregreatlyimprovedwiththeincorporationofthePLGA-PBLGcopolymers.Theelongationatbreakincreasedbyupto150%,andthetensilestrengthincreasedbyupto80%comparedtopurePLGA.Thisimprovementcouldbeattributedtotheformationofmicrophasesbytheself-assemblyoftheblockcopolymers,whichprovideareinforcingeffectforthematerial.Theresultsalsoshowedthatincreasingthemolecularweightofthecopolym