β-环糊精包合有机硫化物的基础研究的综述报告Introductionβ-cyclodextrin(β-CD)isacyclicoligosaccharidecomposedofsevenglucoseunits.Ithasahydrophobiccavityinitsstructure,whichcanbeutilizedtoencapsulateandprotectdifferenttypesofguestmolecules.Amongthem,organicsulfurcompounds(OSCs)havebeenextensivelystudiedduetotheirimportanceinbiology,food,agriculture,andindustry.β-CDcanformstableinclusioncomplexeswithOSCs,enhancingtheirsolubility,bioavailability,andstability.Inthisreview,wesummarizethebasicresearchonβ-CDinclusioncomplexeswithOSCs,includingthemechanisms,methods,properties,andapplications.Mechanismsofβ-CDInclusionComplexationwithOSCsThemechanismsofβ-CDinclusioncomplexationwithOSCscanbeattributedtothreefactors:hydrophobicity,sterichindrance,andhydrogenbonding.OSCsusuallyhavehighhydrophobicityduetothepresenceofsulfuratoms,whichcanleadtotheirlowsolubilityinaqueousmedia.Thehydrophobiccavityofβ-CDcanaccommodatethehydrophobicpartofOSCs,reducingtheirhydrophobicityandincreasingtheiraqueoussolubility.Thesterichindrancebetweenβ-CDandOSCscanalsoplayakeyroleintheformationofinclusioncomplexes.ThesizeandshapeofOSCsmustmatchthesizeandshapeoftheβ-CDcavitytoformastablecomplex.Finally,hydrogenbondingbetweenβ-CDandOSCscanfurtherstabilizetheircomplexation.Thehydroxylgroupsofβ-CDcanformhydrogenbondswiththefunctionalgroupsofOSCs,suchasthesulfuratomortheoxygenatomofthiolorsulfoxidegroups.Methodsofβ-CDInclusionComplexationwithOSCsTherearevariousmethodstoprepareβ-CDinclusioncomplexeswithOSCs.Themostcommonmethodisthekneadingmethod,whichinvolvesmixingtheβ-CDandOSCswithasmallamountofwaterorsolvent,followedbykneadinganddrying.Thismethodcanproducearelativelypureandstableinclusioncomplex,butitrequiresalongprocessingtimeandmayhavelowyield.Anothermethodistheco-evaporationmethod,whichinvolvesdissolvingtheβ-CDandOSCsinasuitablesolvent,followedbyevaporatinganddrying.Thismethodcanproduceahighyieldandgoodstability,butitmayhavelowpurityandrequirecarefulcontrolofthesolventevaporationrate.Othermethodsincludetheco-grindingmethod