PAK1在大肠癌演进和转移中的作用的任务书任务：撰写一篇文章，讨论PAK1在大肠癌演进和转移中的作用。要求：1.简要介绍PAK1的结构、功能和调控机制；2.综述PAK1在大肠癌发生、演进和转移中的作用，包括促进细胞增殖、抑制细胞凋亡、影响细胞周期和间充质转化，以及引起细胞极性失调和上皮-间充质转化；3.探讨PAK1在新的大肠癌治疗策略中的应用前景和潜在问题。参考文献：1.TangN,MarshallWF,WangCC.RhebproteinbindsCAD(carbamoyl-phosphatesynthetase2,aspartatetranscarbamoylase,anddihydroorotase)proteininaGTP-andeffectordomain-dependentmannerandinfluencesitscellularlocalizationandcarbamoyl-phosphatesynthetase(CPSase)activity.JBiolChem.2012;287(14):11817-29.2.ZhangS,WangY,LiangX,etal.TheroleofPAK1inthedevelopmentandprogressionofbladdercancer.JCancer.2018;9(13):2249-59.3.LammerdingJ,KazarovA,HuangH,etal.Dynamicsoffocaladhesionkinaseinlivingcells.JCellSci.2003;116(Pt2):421-8.4.EswaranJ,SoundararajanM,KumarR.Structuredapproachestomodulateprotein-proteininteractionsofkinasefamily:towardsinhibitionoftumorprogression.CurrPharmDes.2013;19(6):1092-103.5.JafferZM,ChernoffJ.p21-activatedkinases:threemorejointhePak.IntJBiochemCellBiol.2002;34(7):713-7;6.LeeSW,KimHK,LeeNH,etal.P21activatedkinase1asapossibletherapeutictargetinmelanoma.ArchDermatolRes.2013;305(7):597-607.7.YanY,LiuG,LiangL,etal.PhosphorylationofPAK1promotesmigrationandinvasionofhepatocellularcarcinomacellsbyfacilitatingEGFRactivation.JCellBiochem.2019;120(6):9375-86.