β-环糊精辅助的嘌呤核苷的水相合成的开题报告摘要：本研究旨在探索β-环糊精辅助下的嘌呤核苷的水相合成方法。采用β-环糊精作为助剂，在水相条件下利用化学发光法和高效液相色谱法对反应产物进行表征和纯化。通过调节反应条件，包括摩尔比、温度和反应时间等，考察β-环糊精对嘌呤核苷水相合成的影响。结果表明，β-环糊精可有效促进嘌呤核苷的水相合成反应，提高产物收率和纯度。本研究为嘌呤核苷的水相合成提供了一种新的策略，具有重要的理论和应用价值。关键词：β-环糊精；嘌呤核苷；水相合成；化学发光法；高效液相色谱法Abstract:Thegoalofthisresearchistoexplorethewater-phasesynthesisofpurinenucleosideswiththeassistanceofβ-cyclodextrin.β-cyclodextrinwasusedasanauxiliaryagent,andthechemicalluminescencemethodandhigh-performanceliquidchromatographywereusedtocharacterizeandpurifythereactionproductsinwater.Byadjustingreactionconditionssuchasmolarratio,temperature,andreactiontime,theeffectofβ-cyclodextrinonthewater-phasesynthesisofpurinenucleosideswasexamined.Theresultsshowedthatβ-cyclodextrincouldeffectivelypromotethewater-phasesynthesisreactionofpurinenucleosidesandimproveproductyieldandpurity.Thisstudyprovidesanewstrategyforthewater-phasesynthesisofpurinenucleosides,whichhasimportanttheoreticalandpracticalvalue.Keywords:β-cyclodextrin;purinenucleosides;water-phasesynthesis;chemicalluminescencemethod;high-performanceliquidchromatography.