200~2011年滨州市结核病流行特征及耐药状况分析的开题报告【摘要】目的：探讨200~2011年滨州市结核病流行特征及耐药状况，为制定预防和控制措施提供参考。方法：采用回顾性研究方法，收集200~2011年滨州市结核病流行资料，包括年度发病率、性别、年龄分布、职业分布、各区县分布情况以及不同类型结核病的比例等资料，同时对2005年后的抗结核药物敏感试验结果进行统计分析。结果：200~2011年滨州市结核病总体发病率呈现上升趋势，男性发病率高于女性，青壮年（15~44岁）居多，农村地区发病率高于城市地区，其中市区发病率最低，各区县发病率差异较大，龙口市发病率最高。不同类型结核病的比例不同，肺结核最为常见，占总发病数的95%以上。抗结核药物耐药情况呈现出多重耐药（MDR-TB）的趋势，其中以肺结核患者多见。结论：滨州市结核病流行特征和耐药状况值得关注，应建立全面有效的结核病管理系统，加强疫情监测与预测，开展结核病的早期发现、早期治疗及预防工作，以期降低结核病的发病率和死亡率。【关键词】滨州市；结核病；流行病学调查；耐药性【Abstract】Objective:Toexploretheepidemiologicalcharacteristicsanddrug-resistancestatusoftuberculosisinBinzhoucityfrom200to2011,andprovideareferenceforthepreventionandcontrolmeasures.Methods:AretrospectivestudywasconductedtocollectdataontheepidemiologyoftuberculosisinBinzhoucityfrom200to2011,includingannualincidence,gender,agedistribution,occupationdistribution,distributionindifferentregions,andtheproportionofdifferenttypesoftuberculosis.Thedrug-sensitivitytestresultsafter2005wereanalyzed.Results:TheoverallincidenceoftuberculosisinBinzhoucityfrom200to2011showedanincreasingtrend,withmaleshavingahigherincidencethanfemales.Youngadults(aged15-44)werethemostaffected,andtheincidencerateinruralareaswashigherthanthatinurbanareas.Theincidencerateintheurbanareawasthelowest,andtherewasasignificantdifferenceintheincidencerateamongdifferentregions,withLongkoucityhavingthehighestincidencerate.Theproportionofdifferenttypesoftuberculosiswasdifferent,andpulmonarytuberculosiswasthemostcommon,accountingformorethan95%ofthetotalincidence.Thedrug-resistancestatusofanti-tuberculosisdrugsshowedatrendofmulti-drugresistance(MDR-TB),whichwasmorecommoninpatientswithpulmonarytuberculosis.Conclusion:Theepidemiologicalcharacteristicsanddrug-resistancestatusoftuberculosisinBinzhoucityareworthattention.Acomprehensiveandeffectivetuberculosismanagementsystemshouldbeestablished,andepidemicmonitoringandpredictionshouldbestrengthenedtocarryoutearlydetection,earlytreatment,andpreventionoftuberculosis,inordertoreducetheincidenceandmortali