LITAF基因在B细胞淋巴瘤发病机制中的生物学功能研究中期报告【摘要】B细胞淋巴瘤（B-celllymphoma）是一种多发性淋巴瘤，常见于年轻人和老年人群体，具有较强的侵袭能力和恶变倾向。LITAF（Lipopolysaccharide-inducedTNF-αFactor）是一个新的转录因子，与TNF-α相关的信号转导途径有关。研究表明，LITAF参与了B细胞淋巴瘤的发病过程。本研究通过对B细胞淋巴瘤不同亚型患者和正常人群的LITAF基因表达水平进行比较分析，发现LITAF表达水平在B细胞淋巴瘤患者中明显升高。进一步实验表明，LITAF通过促进B细胞增殖和凋亡抑制来参与B细胞淋巴瘤的发病机制，可能是作为一个新的治疗靶点的候选物。【关键词】LITAF；B细胞淋巴瘤；转录因子；治疗靶点【Abstract】B-celllymphomaisacommontypeoflymphoma,whichisprevalentinyoungpeopleandtheelderly,andithasahighinvasivenessandmalignanttransformationtendency.LITAF(Lipopolysaccharide-inducedTNF-αFactor)isanewlydiscoveredtranscriptionfactor,whichisassociatedwithTNF-α-relatedsignaltransductionpathways.StudieshaveshownthatLITAFisinvolvedinthepathogenesisofB-celllymphoma.Inthisstudy,theexpressionlevelsoftheLITAFgeneindifferentsubtypesofB-celllymphomapatientsandnormalpopulationswerecomparedandanalyzed,andtheresultsshowedthatLITAFexpressionlevelsweresignificantlyincreasedinB-celllymphomapatients.FurtherexperimentsindicatedthatLITAFisinvolvedinthepathogenesisofB-celllymphomabypromotingB-cellproliferationandapoptosissuppression,anditmaybeapotentialcandidateasanewtherapeutictarget.【Keywords】LITAF;B-celllymphoma;transcriptionfactor;therapeutictarget