Lewisy抗原及膜联蛋白A4在卵巢透明细胞癌中的表达及意义的开题报告【摘要】卵巢透明细胞癌是一种罕见但具有侵袭性的卵巢癌，在临床上难以有效治疗。本研究旨在探讨Lewisy抗原和膜联蛋白A4在卵巢透明细胞癌中的表达及其意义。采用免疫组织化学方法检测了50例卵巢透明细胞癌患者和50例卵巢良性肿瘤患者中Lewisy抗原和膜联蛋白A4的表达水平，并对其在临床上的相关性进行了分析。结果表明，卵巢透明细胞癌患者中Lewisy抗原和膜联蛋白A4的表达水平均显著高于良性肿瘤患者，且其表达呈正相关。此外，Lewisy抗原和膜联蛋白A4的表达水平与卵巢透明细胞癌的恶性程度、远处转移和预后存在显著相关。综上，Lewisy抗原和膜联蛋白A4的表达水平与卵巢透明细胞癌的发生、发展密切相关，并可作为该肿瘤的临床标志物，为其诊断和治疗提供重要参考价值。【关键词】卵巢透明细胞癌；Lewisy抗原；膜联蛋白A4；表达水平；临床意义【Abstract】Ovarianclearcellcarcinomaisararebutaggressiveovariancancerthatisdifficulttotreateffectivelyinclinicalpractice.ThisstudyaimedtoexploretheexpressionandsignificanceofLewisyantigenandmembrane-associatedproteinA4inovarianclearcellcarcinoma.TheexpressionlevelsofLewisyantigenandmembrane-associatedproteinA4weredetectedbyimmunohistochemicalmethodsin50patientswithovarianclearcellcarcinomaand50patientswithbenignovariantumors,andtheirclinicalcorrelationswereanalyzed.TheresultsshowedthattheexpressionlevelsofLewisyantigenandmembrane-associatedproteinA4weresignificantlyhigherinpatientswithovarianclearcellcarcinomathaninpatientswithbenigntumors,andtheirexpressionwaspositivelycorrelated.Inaddition,theexpressionlevelsofLewisyantigenandmembrane-associatedproteinA4weresignificantlycorrelatedwiththemalignancy,distantmetastasis,andprognosisofovarianclearcellcarcinoma.Inconclusion,theexpressionlevelsofLewisyantigenandmembrane-associatedproteinA4arecloselyrelatedtotheoccurrenceanddevelopmentofovarianclearcellcarcinomaandcanbeusedasclinicalmarkersforthediagnosisandtreatmentofthistumor,providingimportantreferencevalue.【Keywords】Ovarianclearcellcarcinoma;Lewisyantigen;Membrane-associatedproteinA4;Expressionlevel;Clinicalsignificance