TAT-NBD抑制NF-κB活化在胆红素诱导大鼠海马神经元凋亡中的作用的开题报告【摘要】随着人类寿命的延长和生活方式的改变，老年性痴呆症的发生率也越来越高，在其中，阿尔茨海默病（AD）约占70%左右。而胆红素在人类体内的含量正常情况下约为10-20μM，而在AD患者体内却经常增加，因此胆红素在AD发病中起到了重要作用，多项研究表明胆红素能够诱导神经元凋亡。同时，NF-κB的活化也会对神经元的保护起到重要作用。本研究的目的是探究TAT-NBD对胆红素诱导大鼠海马神经元凋亡的影响及其机制，为探究胆红素介导神经元凋亡和NF-κB保护机制提供新思路。【关键词】老年性痴呆症；胆红素；神经元凋亡；NF-κB；TAT-NBD【Abstract】Withtheprolongationofhumanlifespanandchangesinlifestyle,theincidenceofseniledementiaisbecominghigherandhigher,amongwhich,Alzheimer'sdisease(AD)accountsforabout70%.Undernormalcircumstances,thecontentofbilirubininhumanbodyisabout10-20μM,whileitoftenincreasesinADpatients.Therefore,bilirubinplaysanimportantroleintheonsetofAD,andmanystudieshaveshownthatbilirubincaninduceneuronalapoptosis.Atthesametime,theactivationofNF-κBalsoplaysanimportantroleintheprotectionofneurons.ThepurposeofthisstudyistoexploretheeffectandmechanismofTAT-NBDonbilirubin-inducedapoptosisofhippocampalneuronsinrats,andtoprovidenewideasforexploringthemechanismofneuronalapoptosismediatedbybilirubinandNF-κBprotectivemechanism.【Keywords】Seniledementia;Bilirubin;Neuronalapoptosis;NF-κB;TAT-NBD