半乳糖基壳聚糖载药纳米粒子的制备及性能研究的中期报告摘要：本文介绍了一种半乳糖基壳聚糖载药纳米粒子的制备方法，利用离子凝胶法，在聚糖溶液中添加适量的药物，然后通过离子凝胶反应得到半乳糖基壳聚糖/药物复合物。再加入交联剂，形成半乳糖基壳聚糖载药纳米粒子。通过TEM观察、动态光散射和紫外可见光谱等手段对纳米粒子进行了表征。结果表明，制备的纳米粒子粒径分布比较均匀，平均粒径为100nm左右，药物载量为15%。关键词：半乳糖基壳聚糖；载药纳米粒子；制备方法；表征Abstract:Thispaperintroducesamethodforpreparingahalf-rhamnosechitosandrug-loadednanoparticle.Iongelationwasusedtoaddanappropriateamountofdrugtothechitosansolution,andthenthehalf-rhamnosechitosan/drugcomplexwasobtainedthroughiongelationreaction.Then,thecrosslinkingagentwasaddedtoformhalf-rhamnosechitosandrug-loadednanoparticles.ThenanoparticleswerecharacterizedbyTEMobservation,dynamiclightscattering,andUV-visiblespectroscopy.Theresultsshowedthatthepreparednanoparticleshadarelativelyuniformparticlesizedistribution,withanaverageparticlesizeofabout100nmandadrugloadingof15%.Keywords:half-rhamnosechitosan;drug-loadednanoparticle;preparationmethod;characterization