鞘内注射抗-脑源性神经营养因子对大鼠后足切割痛觉的影响的开题报告【摘要】本研究旨在探讨鞘内注射抗-脑源性神经营养因子（anti-brain-derivedneurotrophicfactor，anti-BDNF）对大鼠后足切割痛觉的影响。首先，使用手术方法将大鼠后足进行切割，经过数日的康复后，将大鼠随机分为两组。其中一组大鼠接受鞘内注射抗-BDNF，另一组接受生理盐水注射。通过痛觉测试仪对各组大鼠的痛觉敏感度进行检测，包括机械性触痛和热痛。结果显示，接受抗-BDNF治疗的大鼠在机械性触痛和热痛测试中的表现均有所改善，表明抗-BDNF可减轻大鼠后足切割引起的痛觉。本研究的结果表明，抗-BDNF可能是一种针对后足切割痛觉的有效治疗方法。【关键词】鞘内注射；抗-BDNF；大鼠；切割痛觉【Abstract】Theaimofthisstudyistoinvestigatetheeffectofanti-brain-derivedneurotrophicfactor(anti-BDNF)injectedintrathecallyonthecut-inducedpaininrathindpaw.First,rathindpawwascutbysurgery,andafterafewdaysofrecovery,ratswererandomlydividedintotwogroups.Onegroupreceivedintrathecalinjectionofanti-BDNF,whiletheothergroupreceivedsalineinjection.Thepainsensitivityofeachgroupofratswasdetectedbypaintester,includingmechanicalallodyniaandthermalhyperalgesia.Theresultsshowedthattheperformanceofratstreatedwithanti-BDNFwasimprovedinbothmechanicalallodyniaandthermalhyperalgesiatests,indicatingthatanti-BDNFcouldrelievethepaincausedbyhindpawcuttinginrats.Theresultsofthisstudysuggestthatanti-BDNFmaybeaneffectivetreatmentforcut-inducedpaininrathindpaw.【Keywords】intrathecalinjection；anti-BDNF；rat；cut-inducedpain