非小细胞肺癌FETNIMPET/CT乏氧显像临床研究的开题报告（Title）：ClinicalStudyofFETNIMPET/CTHypoxiaImaginginNon-SmallCellLungCancer（Introduction）：Non-smallcelllungcancer(NSCLC)isacommonmalignanttumorwithhighmortality.Hypoxia,whichiscausedbytheabnormalvasculatureinthetumor,isacharacteristicfeatureofsolidtumors,anditisassociatedwithtumorprogression,metastasis,resistancetoradiationandchemotherapy,andpoorprognosis.FETNIMPET/CThypoxiaimagingisarelativelynewimagingtechniquethatallowsfornoninvasivedetectionofhypoxiaintumors.ThisstudyaimstoinvestigatetheclinicalutilityofFETNIMPET/CThypoxiaimaginginNSCLC.（Objectives）：ToevaluatethediagnosticperformanceofFETNIMPET/CThypoxiaimagingindistinguishingbetweenmalignantandbenignpulmonarynodulesinpatientswithNSCLC,andtoexplorethecorrelationbetweenFETNIMPET/CThypoxiaimagingparametersandpathologicalcharacteristicsofNSCLC.（Methods）：Thiswillbeaprospectivestudy.Wewillenroll100patientswithNSCLCdiagnosedbyhistopathologicalexamination.AllpatientswillundergoFETNIMPET/CThypoxiaimagingbeforesurgery.TheFETNIMPET/CTimagedatawillbeanalyzedtoobtainavarietyofhypoxiaimagingparameters,suchasthemaximumstandardizeduptakevalue(SUVmax),tumor-to-backgroundratio(TBR),hypoxicvolume(HV),andtotallesionhypoxicburden(TLHB).Aftersurgery,thepathologicalcharacteristicsofthetumorswillbeobtained,includingTNMstage,histologicaltype,differentiationgrade,lymphnodestatus,andmolecularbiomarkers.（Expectedoutcomes）：WehypothesizethatFETNIMPET/CThypoxiaimagingcanaccuratelyidentifymalignantpulmonarynodulesinpatientswithNSCLC,andthatthereisacorrelationbetweenFETNIMPET/CThypoxiaimagingparametersandpathologicalcharacteristicsofNSCLC.TheresultsofthisstudyareexpectedtoprovideanoninvasiveimagingtooltoaidinthediagnosisandcharacterizationofNSCLC,andtocontributetothedevelopmentofpersonalizedtreatmentstrategiesforNSCLCpatients.（Conclusion）：FETNIMPET/CThypoxiaimaginghasthepotentialtobeavaluableimagingmethodforNSCLCdiagnosisandcharacterization.FurtherstudiesareneededtoconfirmtheclinicalutilityofFETNIMPET/CThypo