HPLC用MWNTs淀粉衍生物类CSPs的研究的开题报告Title:StudyonMWNTs-StarchDerivative-BasedChiralStationaryPhasesforHPLCIntroduction:Currently,thedemandforhigh-resolutionandefficientanalysisofchiralcompoundsindifferentfieldssuchasbiomedicine,pharmaceutical,andfoodindustriesisincreasing.High-performanceliquidchromatography(HPLC)isacommonlyusedtechniqueforseparatingchiralcompounds.Chiralstationaryphases(CSPs)isacrucialfactorthatdeterminestheresolutionofchiralcompounds.Therefore,developingnewCSPswithbetterperformanceishighlydesired.Carbonnanotubes(CNTs)isapromisingmaterialthathasbeenwidelyusedasasupportfordifferentCSPs.Inthisstudy,weaimtosynthesizeCSPsbasedonMWNTs-starchderivativesandevaluatetheirperformanceforHPLCseparationofchiralcompounds.Objectives:1.SynthesizeMWNTs-starchderivativesaschiralstationaryphases(CSPs).2.EvaluatetheperformanceofCSPsusingHPLCtoseparatechiralcompounds.3.OptimizetheseparationconditionsfortheMWNTs-starchderivative-basedCSPs.4.ComparetheperformanceofMWNTs-starchderivative-basedCSPswithexistingCSPs.Methodology:1.SynthesizeMWNTs-starchderivativesbyoxidizingMWNTsandgraftingthemwithstarchderivatives.2.CharacterizethesynthesizedMWNTs-starchderivativesusingFT-IR,Ramanspectroscopy,thermalgravimetricanalysis(TGA),andscanningelectronmicroscopy(SEM).3.EvaluatetheperformanceofCSPsusingHPLCtoseparateaseriesofchiralanalytessuchasaminoacids,pharmaceuticals,andfoodadditives.4.Optimizetheseparationconditionssuchasmobilephasecomposition,pH,andtemperature.5.ComparetheperformanceofMWNTs-starchderivative-basedCSPswithcommercialCSPsandotherCNT-basedCSPs.ExpectedOutcomes:1.SuccessfulsynthesisofMWNTs-starchderivative-basedCSPs.2.ImprovedchiralseparationefficiencyandresolutioncomparedtoexistingCSPs.3.OptimizationofseparationconditionsleadingtofurtherenhancementoftheperformanceofMWNTs-starchderivative-basedCSPs.4.BetterunderstandingofthemechanismbehindtheseparationefficiencyofMWNTs-starchderivative-basedCSPs.Conclusion:ThedevelopmentofMWNTs-starchderivative-basedCSPsh