正常高值血压者MCP-1和MMPs/TIMPs与亚临床靶器官损害的关系的开题报告【摘要】随着生活水平的提高及现代社会的加速发展，高血压已成为全球性的社会问题，其对心血管、肾脏等多个器官的影响已日益受到重视。本文旨在探讨正常高值血压者MCP-1和MMPs/TIMPs与亚临床靶器官损害的关系。通过文献归纳总结，发现正常高值血压者的MCP-1及MMPs/TIMPs与亚临床靶器官损害存在一定关联。随着血压值的升高，血管发生器质性改变的同时，其内皮细胞会释放出MCP-1、MMPs/TIMPs等细胞因子，加速血管内膜的炎症反应及纤维化，进而导致心脏、肾脏等器官的亚临床损害。因此，对于正常高值血压者应及早发现并及时干预，为其避免罹患相关慢性病奠定基础。【关键词】正常高值血压；MCP-1；MMPs/TIMPs；亚临床靶器官损害【Abstract】Withtheimprovementoflivingstandardsandtheaccelerateddevelopmentofmodernsociety,hypertensionhasbecomeaglobalsocialproblem,anditseffectsonmultipleorganssuchasthecardiovascularandkidneyshavereceivedincreasingattention.ThepurposeofthispaperistoexploretherelationshipbetweenMCP-1andMMPs/TIMPsinnormalhigh-valuebloodpressuregroupandsubclinicaltargetorgandamage.Throughliteratureinductionandsummary,itisfoundthatthereisacertaincorrelationbetweenMCP-1andMMPs/TIMPsinnormalhigh-valuehypertensionandsubclinicaltargetorgandamage.Asbloodpressurevaluesincrease,vascularorganicchangesoccur,andendothelialcellsreleasecytokinessuchasMCP-1andMMPs/TIMPs,whichacceleratetheinflammatoryresponseandfibrosisofthevascularintima,leadingtosubclinicaldamagetoorganssuchastheheartandkidneys.Therefore,itisnecessarytoidentifyandinterveneinnormalhigh-valuebloodpressuregroupsasearlyaspossibletolaythefoundationforthemtoavoidrelatedchronicdiseases.【Keywords】Normalhigh-valuebloodpressure;MCP-1;MMPs/TIMPs;subclinicaltargetorgandamage