HPV与FHIT在鼻内翻性乳头状瘤中的相关性研究的开题报告Title:StudyontherelationshipbetweenHPVandFHITininvertedpapillomaofthenasalcavityIntroduction:Invertedpapillomaofthenasalcavityisabenigntumorthatarisesfromtherespiratoryepitheliumofthenasalcavityandparanasalsinuses.Itischaracterizedbythepresenceofglandularandpapillarystructuresthatgrowinaninvertedmannerintotheunderlyingstroma.Thepathogenesisofinvertedpapillomaisstillnotfullyunderstood,butitisbelievedtobeassociatedwithchronicinflammation,geneticalterations,andviralinfections.Humanpapillomavirus(HPV)isawell-knownoncogenicvirusthathasbeenlinkedtoseveraltypesofhumancancers,includingcervical,anal,andoropharyngealcancers.SomestudieshavesuggestedthatHPVmayalsoplayaroleinthedevelopmentofnasalcavityandparanasalsinustumors,includinginvertedpapilloma.TheFHITgeneisatumorsuppressorgenethatislocatedonchromosome3p14.2andisfrequentlyalteredinavarietyofhumancancers.IthasbeenreportedthattheFHITgeneisoftendeletedorsilencedininvertedpapilloma,whichmaysuggestitsinvolvementinthepathogenesisofthistumor.Objective:TheaimofthisstudyistoinvestigatetherelationshipbetweenHPVandFHITexpressionininvertedpapillomaofthenasalcavity.Methods:Thisstudywillbearetrospectiveanalysisofpatientsampleswithconfirmeddiagnosisofinvertedpapillomaofthenasalcavity.HPVstatuswillbedeterminedusingpolymerasechainreaction(PCR)andimmunohistochemistry(IHC)stainingforHPV-relatedproteins.FHITexpressionwillbeanalyzedusingIHCstaining.ResultsandConclusion:TheresultsofthisstudycouldprovideabetterunderstandingofthepathogenesisofinvertedpapillomaanditsrelationshipwithHPVandFHITgeneexpression.Thefindingsmayalsohaveimplicationsforthedevelopmentofnewdiagnosticandtherapeuticstrategiesforthisdisease.