SIN1通过调控上皮细胞间质转化促进肝细胞癌侵袭转移的开题报告【摘要】肝细胞癌是一种高度侵袭性的肿瘤，其侵袭转移是影响患者生存率的一个重要因素。SIN1是一种在人体中广泛表达的信号分子，其在许多恶性肿瘤中被发现具有重要的调节作用。本文介绍了SIN1在肝细胞癌侵袭转移过程中的作用，并阐述了其调节上皮细胞间质转化的机制。我们的研究发现，SIN1能够促进肝细胞癌细胞的移动和侵袭，同时也能调节上皮细胞间质转化相关的分子表达，如E-钙黏蛋白和N-钙黏蛋白等。此外，我们还探究了SIN1在调控肝细胞癌干细胞的作用以及其在细胞代谢方面的影响。这些研究为肝细胞癌治疗的发展提供了新的思路和方向。【关键词】SIN1；肝细胞癌；侵袭转移；上皮细胞间质转化；干细胞；细胞代谢。【Abstract】Hepatocellularcarcinomaisahighlyinvasivetumor,andinvasionandmetastasisarecrucialfactorsaffectingpatientsurvival.SIN1iswidelyexpressedinhumanbodyandhasbeenfoundtoplayanimportantregulatoryroleinmanymalignanttumors.ThisarticleintroducestheroleofSIN1intheinvasionandmetastasisofhepatocellularcarcinoma,andexpoundsitsmechanismofregulatingepithelial-mesenchymaltransition.OurresearchfoundthatSIN1canpromotethemovementandinvasionofhepatocellularcarcinomacells,andalsoregulatetheexpressionofepithelial-mesenchymaltransitionrelatedmolecules,suchasE-cadherinandN-cadherin.Inaddition,wealsoexploredtheroleofSIN1inregulatinghepatocellularcarcinomastemcellsanditseffectsoncellmetabolism.Thesestudiesprovidenewideasanddirectionsforthedevelopmentofhepatocellularcarcinomatreatment.【Keywords】SIN1;hepatocellularcarcinoma;invasionandmetastasis;epithelial-mesenchymaltransition;stemcells;cellmetabolism.