MicroRNA--184在神经胶质瘤中的作用及机制研究中期报告摘要：神经胶质瘤是一种常见的中枢神经系统肿瘤，其发病机制尚不清楚。近年来的研究表明，某些microRNA可能在神经胶质瘤的发生和发展中发挥重要的作用。本研究旨在探讨microRNA-184在神经胶质瘤中的作用及机制。通过实验室的细胞培养实验和分子生物学技术，我们研究了microRNA-184在神经胶质瘤细胞中的表达情况及其对神经胶质瘤的影响。实验结果表明，microRNA-184在神经胶质瘤中显著下调，与恶性程度、预后和治疗反应密切相关。我们还发现，microRNA-184能够抑制神经胶质瘤细胞的增殖和侵袭，并且通过调节该基因靶标来实现这一作用。我们的研究结果表明，microRNA-184可能是一种重要的治疗靶点，可以通过调节其表达来阻止神经胶质瘤的发生和发展。关键词：microRNA-184，神经胶质瘤，增殖，侵袭，治疗靶点Abstract:Gliomasareacommontypeofcentralnervoussystemtumor,andtheirpathogenesisisstillunclear.RecentstudieshaveshownthatcertainmicroRNAsmayplayimportantrolesintheoccurrenceanddevelopmentofgliomas.ThisstudyaimstoexploretheroleandmechanismofmicroRNA-184ingliomas.Throughcellcultureexperimentsandmolecularbiologytechniquesinthelaboratory,westudiedtheexpressionofmicroRNA-184ingliomacellsanditseffectsongliomas.TheresultsshowedthatmicroRNA-184wassignificantlydown-regulatedingliomasandwascloselyrelatedtothedegreeofmalignancy,prognosis,andtreatmentresponse.WealsofoundthatmicroRNA-184couldinhibittheproliferationandinvasionofgliomacellsandachievethiseffectbyregulatingthetargetgenes.OurresearchresultssuggestthatmicroRNA-184maybeanimportanttherapeutictarget,anditsexpressioncanbeadjustedtopreventtheoccurrenceanddevelopmentofgliomas.Keywords:microRNA-184,glioma,proliferation,invasion,therapeutictarget