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YuanXH,etal./NeuralRegenerationResearch.2013;8(35):3325-3333.www.nrronline.orgNEURALREGENERATIONRESEARCHVolume8,Issue35,December2013doi:10.3969/j.issn.1673-5374.2013.35.007[http://www.nrronline.org;http://www.sjzsyj.org]YuanXH,LiuXY,TangQP,DengYL.Pain-relatedmediatorsunderlieincision-inducedmechanicalnociceptioninthedorsalrootganglia.NeuralRegenRes.2013;8(35):3325-3333.Pain-relatedmediatorsunderlieincision-inducedmechanicalnociceptioninthedorsalrootganglia**XiuhongYuan,XiangyanLiu,QiupingTang,YunlongDengInstituteofPsychosomaticHealth,theThirdXiangyaHospitalofCentralSouthUniversity,Changsha410013,HunanProvince,ChinaXiuhongYuan,M.D.,Attendingphysician.Correspondingauthor:YunlongDeng,M.D.,Chiefphysician,InstituteofPsychosomaticHealth,theThirdXiangyaHospitalofCentralSouthUniversity,Changsha410013,HunanProvince,China,deng0087@xy3yy.com.Received:2013-08-07Accepted:2013-11-09(N201305013)Funding:ThisresearchwassupportedbytheScienceandTechnologyProjectofHunanProvince,No.2010SK3119and125TalentsProjectof3rdXiangyaHospital,CentralSouthUniversityinChina.Authorcontributions:YuanXHwasinchargeofexperiments,studydesignandpaperwriting.DengYLwasresponsibleforstudydesignandpaperwriting.LiuXYandTangQPperformedtheexperimentsandstatisticalanalysis.Allauthorsapprovedthefinalversionofthepaper.Conflictsofinterest:Nonedeclared.Ethicalapproval:AllprotocolswereapprovedbytheAnimalEthicsCommitteeofCentralSouthUniversity,China.Authorstatements:Themanuscriptisoriginal,hasnotbeensubmittedtoorisnotunderconsiderationbyanotherpublication,hasnotbeenpreviouslypublishedinanylanguageoranyform,includingelectronic,andcontainsnodisclosureofconfidentialinformationorauthorship/patentapplication/fundingsourcedisputations.GraphicalAbstractThesurgerydecreasedwithdrawalthresholdattheoperatedhindpaw.Plantarincisiononthelefthindpawwasperformedinrats.Ourfindingsindicatethat,pain-relatedmediatorsinducedbyincisionsurgeryindorsalrootgangliaofratspossiblyunderliemechanical
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