Steglich酯化反应在DMAP催化下，以DCC为偶联试剂的酯化方法。1978年Steglich首先提出【Angew.Chem.Int.Ed.1978,17,522】，该方法条件温和，可用于位阻大的或对酸敏感底物的酯化，适用于从叔丁醇制备叔丁酯。而传统的Fischer酯化法（酸催化酯化）会导致叔丁醇消除。该法也可用于硫代酸酯的合成。Keck在研究用此方法合成大环内酯时，发现加入DMAP.HCl可以提高质子转移效率，提高酯化收率。【J.Org.Chem.1985,50,2394】反应机理首先羧酸先和DCC反应生成活性酯，接着和DMAP交换生成活性酰胺，醇进攻活性酰胺，生成酯。反应实例此方法合成天然产物hapalosin，产率比Yamguchi法（Yamaguchi酯化反应）产率高。【J.Comb.Chem.2007,9,386】A500-mL,one-neckedflaskequippedwithacalciumchloridedryingtubewaschargedwith28.83g(0.20mol)ofmonoethylfumarate,200mLofdrydichloromethane,44.47g(0.60mol)oftert-butylalcohol,and2.00g(0.16mol)of4-dimethylaminopyridine.Thesolutionwasstirredandcooledinanicebathto0°Cwhile45.59g(0.22mol)ofdicyclohexylcarbodiimidewasaddedovera5-minperiod.Afterafurther5minat0°Ctheicebathwasremovedandthedark-brownreactionmixturewasstirredfor3hatroomtemperature.ThedicyclohexylureathathasprecipitatedwasremovedbyfiltrationthroughafrittedBüchnerfunnel(G3),andthefiltratewaswashedwithtwo50-mLportionsof0.5Nhydrochloricacidandtwo50mLportionsofsaturatedsodiumbicarbonatesolution.Duringthisproceduresomeadditionaldicyclohexylureawasprecipitated,whichwasremovedbyfiltrationofbothlayerstofacilitatetheirseparation.Theorganicsolutionwasdriedoveranhydroussodiumsulfateandconcentratedwitharotaryevaporator.Theconcentratewasdistilledunderreducedpressure,affordingafterasmallforerun,30.5–32.5(76–81%)oftert-butylethylfumarate,bp105–107°C(12mm)。【OrganicSyntheses,Coll.Vol.7,p.93(1990);Vol.63,p.183(1985)】编辑自：《有机人名反应、试剂与规则》，黄培强等。