2,2′—二磺酸基联苯胺合成工艺的研究的综述报告.docx
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2,2′—二磺酸基联苯胺合成工艺的研究的综述报告.docx

2,2′—二磺酸基联苯胺合成工艺的研究的综述报告.docx

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2,2′—二磺酸基联苯胺合成工艺的研究的综述报告2,2'-diaminodiphenylsulfoneisanimportantintermediateintheproductionofsulfonamidedrugsandengineeringplastics.Thesynthesisof2,2'-diaminodiphenylsulfonebysulfonationofdiphenylaminehasbeenapopularresearchtopicforalongtime.Amongvarioussynthesismethods,thesulfonationofdiphenylaminewithfumingsulfuricacidisthemostwidelyusedone.Inthisreview,thesynthesisprocess,reactionmechanism,influencingfactors,andprocessoptimizationof2,2'-diaminodiphenylsulfonewillbesystematicallysummarized.Thesynthesisof2,2'-diaminodiphenylsulfonefromdiphenylamineandfumingsulfuricacidcanbedividedintothreestages:sulfonationofdiphenylamine,oxidationofthesulfonatedproduct,andhydrolysis.Inthefirststage,diphenylamineissulfonatedbyfumingsulfuricacidtoform2,2'-diaminodiphenylsulfonedisulfonicacid.Thereactionequationisasfollows:C12H11N+2H2SO4→C12H8N2O4S2+2H2OInthesecondstage,thesulfonatedproductisoxidizedbyanoxidant,suchasnitricacidorhydrogenperoxide,togenerate2,2'-diaminodiphenylsulfonesulfonicacid.Thereactionequationisasfollows:C12H8N2O4S2+2HNO3→C12H8N2O4S3+2NO2+2H2OInthelaststage,thesulfonicacidgroupoftheproductishydrolyzedbyabase,suchassodiumhydroxide,toobtainthetargetproduct,2,2'-diaminodiphenylsulfone.Thereactionequationisasfollows:C12H8N2O4S3+2NaOH→C12H10N2O2S+Na2SO4+H2OThereactionmechanismofthesulfonationofdiphenylamineiscomplex,involvingelectrophilicaromaticsubstitution,nitration,andnitrosation.Theadditionoffumingsulfuricacidtodiphenylaminecangeneratediphenylaminebisulfateandfumingnitricacid.Thebisulfateioncanreactwithdiphenylaminetoformdiphenylaminesulfonicacidandsulfurtrioxide.Thesulfurtrioxidethenreactswithfumingnitricacidtoproducenitrosylsulfuricacid,whichfurtherreactswithdiphenylaminesulfonicacidtoform2,2'-diaminodiphenylsulfonedisulfonicacid.Theinfluencingfactorsofthesynthesisprocessincludethemolarratioofdiphenylaminetofumingsulfuricacid,reactiontemperature,reactiontime,andthepresenceofimpurities.Theappropriatemolarratioofdiphenylaminetofumingsulfuricacidis