神经营养因子与神经生长和修复.pptx
上传人:王子****青蛙 上传时间:2024-09-14 格式:PPTX 页数:33 大小:14MB 金币:10 举报 版权申诉
预览加载中,请您耐心等待几秒...

神经营养因子与神经生长和修复.pptx

神经营养因子与神经生长和修复.pptx

预览

免费试读已结束,剩余 23 页请下载文档后查看

10 金币

下载此文档

如果您无法下载资料,请参考说明:

1、部分资料下载需要金币,请确保您的账户上有足够的金币

2、已购买过的文档,再次下载不重复扣费

3、资料包下载后请先用软件解压,在使用对应软件打开

神经营养因子与神经生长和修复1934:VictorHamburgerdiscoveredthatremovalofalimbbudresultedinreducednumbersofsensoryandmotorneuronsinthespinalcord、EffectofRemovingorAugmentingNeuralTargetsontheSurvivalofRelatedNeuronsBasedonhislimb-budexperiments,V、Hamburgerhypothesizedthatthetargetsofinnervatingneuronsprovidesignalsthatrecruitundifferentiatedcellstodevelopintosensoryormotorneurons、1954:neuriteoutgrowthassayNGF:sympatheticneuronsandsomesensoryneuronsNeurotrophinsBDNF(brainderivedneurotrophicfactor)oncorticalneurons101112Trkreceptorsignaling17StructureofneurotrophicFactorreceptorsAlternativesplicinggeneratesmanyTrkreceptorisoformsp75NTRstructureModelsforTrkandp75NTRinteractionTheeffectofNT/NTRknockoutsonneuronsintheDRGOuraxonscanbe>1minlength---howdoestheneurotrophin/receptorplexsignaltotheneuronalcellbody?Campenot,RB(1977)Localcontrolofneuritedevelopmentbynervegrowthfactor、ProcNatlAcadSciUSA、74(10):4516-9、ActivatedTrkcansignallocallyandretrogradelyusingdifferentsignallingpathwaysDifferentialcontrolofTrkAtraffickingandsignalingmayalsobethebasisforthedifferentfunctionsofNGFandNT-3InvitroassayshaveshownthatNTsenhancebothaxonalanddendriticgrowthInvivo,thesituationismoredifficulttostudyNT’srolesinneuronaldevelopmentandfunctionNT’sintheCNSCytokinesandGrowthFactorsintheNervousSystemSummaryWhatisagrowthfactor?Whatisatrophicfactor?
立即下载