HYPERLINK"http://124.16.31.131:8080/Jweb_sjzs"中国神经再生研究(英文版)HYPERLINK"http://124.16.31.131:8080/Jweb_sjzs/CN/article/showTenYearVolumnDetail.do?nian=2013"2013,HYPERLINK"http://124.16.31.131:8080/Jweb_sjzs/CN/article/showTenYearVolumnDetail.do?nian=2013"Vol.8HYPERLINK"http://124.16.31.131:8080/Jweb_sjzs/CN/volumn/volumn_1137.shtml"Issue(1):64-69DOI:10.3969/j.issn.1673-5374.2013.01.008HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"参与局灶性脑缺血再灌注损伤修复的轴突导向因子1Expressionofnetrin-1anditsreceptors,deletedincolorectalcanceranduncoordinatedlocomotion-5homologB,inratbrainfollowingfocalcerebralischemiareperfusioninjury全文:HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"PDF(279KB)摘要胚胎期轴突导向因子1通过与结直肠癌缺失基因抗原及UNC5B受体结合，在神经传导通路的构建和神经细胞的定向迁移过程中起导向作用。利用线栓法建立大鼠大脑中动脉缺血再灌注模型，免疫荧光检测显示，再灌注1d后轴突导向因子1和结直肠癌缺失基因抗原在缺血半暗区中表达上调，于14d达到高峰，21d后表达减弱；UNC5B表达无明显变化。免疫荧光检测显示，轴突导向因子1表达在神经元胞体内和小血管周围，在星形胶质细胞及小胶质细胞中无表达；轴突导向因子1还表达于小血管周围，而直肠癌缺失基因抗原定位于神经元和星形胶质细胞的胞膜和突起。上述结果验证轴突导向因子1可能通过结直肠癌缺失基因抗原受体参与缺血再灌注后的损伤修复及神经元保护作用。关键词：HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"神经再生；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"脑损伤；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"脑缺血再灌注；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"结肠癌缺失蛋白；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"神经元；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"基金资助文章；HYPERLINK"http://www.sjzsyj.org:8080/Jweb_sjzs/CN/abstract/abstract23.shtml"图片文章；Abstract:Netrin-1iscurrentlyoneofthemosthighlystudiedaxonguidancefactors.Netrin-1iswidelyexpressedintheembryoniccentralnervoussystem,andtogetherwiththedeletedincolorectalcanceranduncoordinatedlocomotion-5homologBreceptors,netrin-1playsaguidingroleintheconstructionofneuralconductionpathwaysandthedirectionalmigrationofneuronalcells.Inthis