会计学前言奥曲肽主要(zhǔyào)成分、分子式、分子量奥曲肽药理作用奥曲肽临床(línchuánɡ)适应症奥曲肽与生长抑素的比较(bǐjiào)目的研究(yánjiū)方法排除(páichú)标准步骤(bùzhòu)与方法注意事项观察(guānchá)项目判定(pàndìng)标准肝功能分级(fēnjí)标准食管静脉曲张(jìngmài-qūzhāng)内镜下分级出血停止(tíngzhǐ)判定标准继续(jìxù)出血或再出血判定标准疗效判定(pàndìng)标准生物等效性判断(pànduàn)标准试验终止(zhōngzhǐ)标准不良反应评价(píngjià)标准统计学分析(fēnxī)结果表1病例完成情况治疗(zhìliáo)组对照组合计人民医院例数15924%62.537.5100天津总医院例数151126%57.742.3100协和医院例数16420%80.020.0100西京医院例数14620%70.030.0100合计例数603090%66.733.3100表2基本情况治疗组对照组统计量p年龄49.57±12.8350.63±14.22ｔ=-0.3590.721性别(xìngbié)男4319ⅹ2=0.4680.421女1711身高（cm）167.31±7.08168.21±6.90ｔ=0.5620.576体重（kg）63.76±9.8462.73±8.95ｔ=0.4670.641SBP(mmHg)106.42±15.49109.50±18.12ｔ=-0.8360.406DBP(mmHg)65.81±9.0466.83±10.54ｔ=-0.4750.636脉率(次/分)91.48±14.7792.43±13.66ｔ=-0.2950.769Child分级A2413ⅹ2=2.0960.351B2810C87两组之间无统计学差异表5两组治疗前实验室指标的比较(bǐjiào)项目例数MeanｓｔpALT（u/L）6039.0030.980.7090.4803034.6019.56AST（u/L）5955.2747.950.7340.4653048.2329.87TBIL（mg/L）5718.1012.40-1.0230.3092522.5026.40γ-GT（u/L）5664.4863.57-0.4660.6433074.76141.11ALB（g/L）5929.806.700.1200.9053029.707.20ALP（u/L）5593.5264.34-0.9470.34630108.5679.31BUN（mg/L）59221.80132.400.2950.76930213.40111.50项目(xiàngmù)例数Meanｓｔp表6终止(zhōngzhǐ)病例情况中心编号医院住院号组别脱落时间原因1人民医院72648治疗组24h继续出血且量大而停药2天津总院168871对照组36h继续出血改三腔管止血2天津总院463758治疗组12h继续出血改内镜下止血2天津总院473778对照组24h继续出血改内镜下止血3协和医院544931治疗组24h继续出血自行退出3协和医院547549对照组24h出血增加、血压下降表7两组不同(bùtónɡ)时间出血情况比较（ITT）例数Meanｓｔp治疗前治疗60882.67593.360.2750.784对照30850.00373.01治疗后12h31449.03379.620.7040.48520375.00344.7024h21247.62131.79-2.1490.0409577.78690.6136h11236.36109.750.2620.7976216.66204.1248h7235.71254.480.6670.5233133.3357.73两组之间无统计学差异表8治疗组治疗前后(qiánhòu)出血差值（ml）治疗后例数Meanｓp12h前-后31633.23643.38024h前-后21909.52679.09036h前-后11927.27457.91048h前-后7978.57683.650.009表9对照组治疗(zhìliáo)前后出血差值（ml）治疗(zhìliáo)后例数Meanｓp12h前-后20610.00414.09024h前-后9411.11596.750.07536h前-后6816.67376.390.00348h前-后3766.67230.940.029表10两组治疗(zhìliáo)前后出血差值（ml）治疗(zhìliáo)后组别例数Meanｓp12h治疗(zhìliáo)组31633.23643.380.887对照组20610.00414.0924h治疗(zhìliáo)组21909.52679.080.067对照组9411.11596.7536h