临床研究Linchuangyanjiu《中国医学创新》第21卷第11期（总第653期）2024年4月麝香通心滴丸联合瑞舒伐他汀治疗冠心病合并高胆固醇血症的效果和对肝功能的影响*杨云帆①马维娜①张春亚②【摘要】目的：研究麝香通心滴丸联合瑞舒伐他汀治疗冠心病（CHD）合并高胆固醇血症的效果和对肝功能的影响。方法：选取2020年6月—2022年6月在上海市嘉定区中心医院住院治疗的60例CHD合并高胆固醇血症患者，按照随机数字表法将其分为两组，每组30例，单一组给予瑞舒伐他汀治疗，联合组在单一组基础上加以麝香通心滴丸治疗，对比两组临床疗效、血脂水平、内皮功能及肝功能。结果：治疗6个月后，联合组总有效率高于单一组，差异有统计学意义（P<0.05）；联合组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）均低于单一组，高密度脂蛋白胆固醇（HDL-C）高于单一组，差异均有统计学意义（P<0.05）；联合组一氧化氮（NO）高于单一组，内皮素-1（ET-1）低于单一组，差异均有统计学意义（P<0.05）；两组谷丙转氨酶（ALT）、谷草转氨酶（AST）均升高，但联合组均低于单一组，差异均有统计学意义（P<0.05）。结论：使用麝香通心滴丸联合瑞舒伐他汀治疗CHD合并高胆固醇血症具有良好效果，能够有效降低患者血脂水平，改善内皮功能，且对肝功能影响较小。【关键词】麝香通心滴丸瑞舒伐他汀冠心病高胆固醇血症肝功能EffectofShexiangTongxinDiwanCombinedwithRosuvastatinintheTreatmentofCoronaryHeartDiseaseComplicatedwithHypercholesterolemiaandItsInfluenceonLiverFunction/YANGYunfan,MAWeina,ZHANGChunya.//MedicalInnovationofChina,2024,21(11):024-028[Abstract]Objective:TostudytheeffectofShexiangTongxinDiwancombinedwithRosuvastatinoncoronaryheartdisease(CHD)complicatedwithhypercholesterolemiaanditsinfluenceMethod:onliverSixtyfunction.patientswithCHDcomplicatedwithhypercholesterolemiawhowerehospitalizedinShanghaiJiadingDistrictCentralHospitalfromJune2020toJune2022wereselectedanddividedintotwogroupsaccordingtorandomnumbertablemethod,with30casesineachgroup.ThesinglegroupwastreatedwithRosuvastatin,andthecombinedgroupwastreatedwithShexiangTongxinDiwanonthebasisofthesinglegroup.Theclinicalefficacy,bloodlipidlevel,endothelialfunctionandliverfunctionwerecomparedbetweenResult:thetwoAftergroups.6monthsoftreatment,thetotaleffectiverateofthecombinedgroupwashigherthanthatofthesinglegroup,thedifferencewasstatisticallysignificantP<0.05);(thetotalcholesterol(TC),triglyceride(TG),andlow-densitylipoproteincholesterol(LDL-C)ofthecombinedgroupwerelowerthanthoseofthesinglegroup,whilehigh-densitylipoproteincholesterol(HDL-C)washigherthanthatofthesinglegroup,thedifferenceswerestatisticallyP<0.05);thesignificantnitricoxide((NO)incombinationgroupwashigherthanthatinsinglegroup,a