URI对宫颈癌细胞顺铂耐药性及迁移能力的影响中期报告【摘要】宫颈癌是女性常见恶性肿瘤之一，铂类化疗药物是其治疗的重要手段，但顺铂耐药性严重影响其疗效。本研究旨在探讨URI对宫颈癌细胞顺铂耐药性及迁移能力的影响。初步实验结果表明，URI可以增加顺铂对宫颈癌细胞的敏感性，同时降低其迁移能力。进一步的研究将开展对URI调节宫颈癌细胞顺铂耐药性和迁移能力的具体机制进行深入探讨。【关键词】宫颈癌；顺铂耐药性；迁移能力；URI【Abstract】Cervicalcancerisoneofthecommonmalignanttumorsofwomen,andplatinum-basedchemotherapydrugsareanimportanttreatmentforit,butcisplatinresistanceseriouslyaffectsitsefficacy.TheaimofthisstudywastoinvestigatetheeffectofURIoncisplatinresistanceandmigrationabilityofcervicalcancercells.PreliminaryexperimentalresultsshowedthatURIcouldincreasethesensitivityofcervicalcancercellstocisplatin,whilereducingtheirmigrationability.FurtherresearchwillbeconductedtofurtherexplorethespecificmechanismsofURIregulationofcisplatinresistanceandmigrationabilityincervicalcancercells.【Keywords】cervicalcancer;cisplatinresistance;migrationability;URI