我国糖尿病患病率9.7%，其中2型糖尿病（T2DM)占90%，绝大多数T2DM患者存在IR；IR定义：是指胰岛素效应器官对正常剂量胰岛素反应性降低，导致胰岛素敏感组织（脂肪、肝脏和肌肉）对葡萄糖摄取和利用障碍。胰岛素（Insulin)的生理功能胰岛素抵抗综合征（IRS)的特征生理及IR时的胰岛素受体后信号通路胰岛素抵抗人群CVD发病率显著升高可能机制：代偿性高胰岛素血症抑制肝脏产生和释放过多葡萄糖，但内脏脂肪有过多脂肪分解导致游离脂肪酸释放，并抑制肌肉摄取和利用葡萄糖；FFA通过脂毒性促进AS的发生胰岛素抵抗伴随的高血压、高血糖、高血脂等因素导致内皮功能失调为起始环节的AS的发生。颈动脉内膜、中膜增厚是糖尿病患者亚临床AS的标志，胰岛素敏感性与颈总动脉内膜、中膜厚度呈负相关。IR是心血管疾病和2型糖尿病发生的共同特征肥胖(Obesity），IR和T2DM腹部脂肪堆积（VisceralFatDeposition）中心型肥胖（CentralObesity）与IRVazquez‐VelaME,2008Planat-BenardV,2004MasoodiM,2014RosenED,2006;MasoodiM2014Vazquez‐VelaME,2008肥胖、脂肪功能失调和胰岛素抵抗Adiponectin:脂联素Leptin:瘦素TNF-:肿瘤坏死因子IL-6:白介素6Resistin:抵抗素Obesity,FFA,inflammationandIRProliferation,differentiationClC-3isimportantintheregulationofcellvolume,proliferationandapoptosisClC-3isimportantintheregulationofcellularapoptosisShi,XL,etal.Hypertension2007;LiuYJ，etal:Hypertension2010ThomasJ.Jentsch,etal.TheJournalofNeuroscience,October15,2008.28(42):10587–10598ClC-3proteinisimportantintheregulationofcellularapoptosisClC-3encodesvolume-regulatedchloridechannelinvascularsmoothmusclecellsandinvolvedinVSMCproliferationShi,XL,Hypertension2007;LiuYJ，Hypertension2010StatinsThehigh-sucrose-fatdiet(HSFD)andstreptozotocin(STZ)-induceddiabeticratsexhibitsenhancedClC-3proteinexpressioninadiposetissue,whichispositivelycorrelatedwithHOMA-IRvaluesClC-3silencingcouldimproveglucoseandlipiddisorders,aswellasimpairedinsulinsensitivityinT2DMJentsch,TJ.J.Neurosci.,2008PalmitateincreasedClC-3mRNAexpressionin3T3-L1preadipocytesusingreal-timeRT-PCRanalysisClC-3siRNAsignificantlyimprovedpalmitate-inducedapoptosisin3T3-L1preadipocytesERstressinduceapoptosisindiabetesClC-3siRNASummary