2024NO.2中外医疗药物与临床China&ForeignMedicalTreatmentDOI：10.16662/j.cnki.1674-0742.2024.02.093地佐辛对下肢骨折患者腰硬联合麻醉术后疼痛程度的影响郑燕玲1，廖文辉2，林琳31.福建省龙岩人民医院疼痛科，福建龙岩364000；2.福建省龙岩人民医院骨科，福建龙岩364000；3.福建省龙岩人民医院麻醉科，福建龙岩364000［摘要］目的研讨地佐辛对下肢骨折患者腰硬联合麻醉术后疼痛程度的影响。方法方便选取2021年5月—2023年2月在福建省龙岩人民医院行腰硬联合麻醉手术的74例下肢骨折患者为研究对象，按照随机数表法分为对照组和观察组，每组37例。对照组予以腰硬联合麻醉，观察组基于对照组麻醉条件予以地佐辛静脉注射，比较两组不同时点的基础体征指标、术后镇静深度、疼痛程度以及镇痛安全性。结果切皮时、术后1h，观察组的收缩压（SystolicPressure,）、SBP舒张压（DiastolicPressure,）DBP以及心率值均低于对照组，差异有统计学意义（P均<0.05）。术后1、3、6及12h，观察组视觉模拟评分法（VisualAnalogueScale,）VAS得分均低于对照组，警觉/镇静观察评分（Observer'sAssessmentofAlertness/Sedation,）得OAA/S分均高于对照组，差异=有统计学意义（P均<0.05）。观察组不良反应发生率（8.11%）低于对照组（27.03%），差异有统计学意义（χ24.572，P=0.032）。结论在腰硬联合麻醉后辅以地佐辛治疗，能够有效改善下肢骨折患者的生命体征，减轻其术后疼痛程度，减少不良反应的发生。［关键词］下肢骨折；地佐辛；腰硬联合麻醉；术后疼痛程度；镇痛安全性［中图分类号］R5［文献标识码］A［文章编号］1674-0742（2024）01(b)-0093-04EffectofDezocineonPostoperativePainLevelsafterCombinedSpinalandEpiduralAnesthesiainPatientswithLowerExtremityFracturesZHENGYanling1,LIAOWenhui2,LINLin31.DepartmentofPain,LongyanPeople'sHospital,Longyan,FujianProvince,364000China;2.DepartmentofOrthope⁃dics,LongyanPeople'sHospital,Longyan,FujianProvince,364000China;3.DepartmentofAnesthesiology,LongyanPeople'sHospital,Longyan,FujianProvince,364000China[Abstract]ObjectiveTostudytheeffectofdezocineonpostoperativepaininpatientswithlowerlimbfractureundercombinedspinalandepiduralanesthesia.MethodsAtotalof74patientswithlowerextremityfracturewhounderwentcombinedlumbarandepiduralanesthesiainLongyanPeople'sHospitalofFujianProvince2021tofromFebruMay⁃ary2023wereconvenientlyselectedasthestudyobjects,andweredividedintocontrolgroupandobservationgroupaccordingtorandomnumbertablemethod,37withcasesineachgroup.Thecontrolgroupwasgivenlumboepiduralanesthesia,andtheobservationgroupwasgivendezocineintravenousinjectionbasedontheanesthesiaconditionsofthecontrolgroup.Thebasicsignsindexes,postoperativesedationdepth,paindegreeandanalgesicsafetyofthetwogroupswerecomparedatdifferenttimeResultspoints.Th