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INNATEDEFENSESIMMUNERESPONSETHEIMMUNESYSTEMCHARACTERISTICSOFIMMUNERESPONSESelf-AntigensAntigensonhostcellsNotrecognizedasimmunogenicbyhost’simmunesystemAconditioncalledtoleranceINDUCTIONOFIMMUNERESPONSEBCELLSANTIBODIESANTIBODYCLASSIFICATIONDevelopfromstemcellsthatmatureunderhormonalcontrolinthymusMakeupthecell-mediatedimmuneresponseHelptodestroyinfectedcellsCoordinatetheoverallimmuneresponseTYPESOFTCELLST-CELLRECEPTORTcell(lymphocyte)withaT-cellreceptoronitssurfaceANTIBODYPRODUCTIONHistocompatibilityAntigens(HumanLeukocyteAntigens)MajorHistocompatibilityComplex(MHC)INNATEIMMUNITYINNATEIMMUNITYMainMediatorsLysosomalenzymesCytokinesComplementproteinsAcutephaseproteinsACQUIREDIMMUNITYActiveNaturalexposureImmunizationPassiveDoesn’tinvolvehost’simmuneresponseAntibodies&TcellstransferredtorecipientTemporaryimmunityPrimary5–7daysafterexposureDominatedbyIgMLesseramountsofIgGHUMORALIMMUNITYCELL-MEDIATEDIMMUNITYACUTEINFLAMMATORYRESPONSEMACROSCOPICHALLMARKSOFINFLAMMTIONAccumulationoffluidandcellsattheinflammatorysiteMASTCELLSMAJORVASOACTIVEAMINESOFINFLAMMATIONACUTEPHASERESPONSEFeverSomnolenceAnorexiaChangesinplasmaproteinsynthesisAlteredsynthesisofendocrinehormonesMajoracutephaseproteins(APP)C-Reactiveprotein(CRP)SerumamyloidA(SAA)NegativeAPPAlbuminTransthyretinTransferrinC-REACTIVEPROTEINPLASMAPROTEINSYSTEMCOMPLEMENTSYSTEMCLOTTINGSYSTEMKININSYSTEMINHIBITORYINFLAMMATORYENZYMESPhagocyticleukocytesNeutrophilsMacrophagesEosinophilsPlateletsLymphocytesPHAGOCYTICCELLSOPSONINSENDOTHELIALCELLSPOLYMORPHONUCLEARNEUTROPHIL(PMN)MONOCYTESMACROPHAGESROLEOFMACROPHAGESEOSINOPHILSCELLULARPRODUCTSINTERLEUKINSLYMPHOKINESCHEMOKINESINTERFERONCHRONICINFLAMMATIONRESOLUTION&REPAIRWOUNDHEALINGNEONATALCONSIDERATIONGERIATRICCONSIDERATIONS感谢您的观看(guānkàn)！内容(nèiróng)总结
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