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Anesthesiology,Yesterday,TodayandTomorrowTheFirstAnesthesiologist.1"AndtheLordGodcausedadeepsleeptofalluponAdam,andheslept."Genesis2:21.ManagingPainBeforeAnesthesiaMostcommon,Opiumpoppy,Papaversomniferum,MandragoraormandrakefromAtropamandragora,belladonnafromtheMorningGlory,marijuanaorCannabisindica.Inthose“dark”daysmanypatientsapproachedsurgeryasthroughfacingexecution,anoftenappropriateassessmentofuncontainedrisks,includingpain,hemorrhage,shockandpostoperativeinfection.Theeasiestpaintobearissomeoneelse’s.SeishuHanaoka,1760-1835.2Hanaoka1805GoldenEpochsofAnesthesiologyGoldenEpochsofAnesthesiologyETHERDAY.3WilliamThomasMorton1819-68.3EtherCrawfordWilliamsonLong(1815-1878).4TheanniversaryofLong’sgreataccomplishment,March30th,iscelebratedintheUnitedStatesas“Doctor’sDay”,andallmedicalspecialtiesarehonored.SirHumphreyDavy(1778-1829)HumphreyDavy.4Drawingfromthe18thcenturydepictingtherecreationaluseofnitrousoxide-laughinggasHoraceWells(1815-1848).5Thenextday,WellsaskedColtontoadministerN2O,whileanassociateextractedatooth.DemonstratedN2OatHarvard01/1845,patientcried,studentshissed“Humbug.”Addictedtochloroform.Arrestedforthrowingacidonprostitutes,committedsuicideinjail.Pushedaknowntoxintounconsciousness.InhalationlandmarksGoldenEpochsofAnesthesiologyKarlKoller1857-1944LandmarksinRegionalAnesthesiaVirginiaApgar1909-1974.6GoldenEpochsofAnesthesiologyJohnS.Lundy,1894-1973GoldenEpochsofAnesthesiologyNeuromuscularBlockingDrugsPaleopharmacologyofcurarePaleopharmacologyofcurareNMBAsClaudeBernard,1857GoldenEpochsofAnesthesiologyEllisonPierceMD,Pres.ASA1984.HarveyCushing,1869-1939PulseOximetry,1973,1983.ModernAnesthesiaMachine.AnesthesiaMortality.7GoldenEpochsofAnesthesiologyReferencesReferences2SeishuHanaoka,1760-1835.2HoraceWells(1815-1848).5Thenextday,WellsaskedColtontoadministerN2O,whileanassociateextractedatooth.DemonstratedN2OatHarvard01/1845,patientcried,studentshissed“Humbug.”Addictedtochloroform.Arrestedforthrowingacidonprostitutes,committedsuicideinjail.Pus