并非所有暴露个体均患病冀医四院头颈部鳞癌、胃癌及胰腺癌细胞株中TβRⅠ基因甲基化与其表达降低有关。研究目的基因MethylationanalysisofTβRⅠandTβRⅡintumortissue(T)andcorrespondingnormaltissues(N).u:indicatesthepresenceofunmethylatedgenes;m:indicatesthepresenceofmethylatedgenes.Cases1:tumor-specificmethylation;Case2:thetumorisfullymethylated,whereasthecorrespondingnormaltissuehasaveryfaintbanddemonstratingmethylation;Case3:bothoftumorandcorrespondingnormaltissueunmethylated.UnmethylatedFrequencyofTβRⅠ,ⅡgenemethylationinESCCandadjacentnon-canceroustissuesTherelationshipbetweenTβRⅠ,ⅡgenemethylationandclinicaldatainESCCFrequencyofTβRⅠ,ⅡgenemethylationincommoninESCCandadjacentnon-canceroustissueTherelationshipbetweenTβRⅠ,ⅡgenemethylationincommonandclinicaldatesinESCC目前认为DNA甲基化主要在转录水平抑制基因的表达，TGF-β受体Ⅰ、Ⅱ基因的甲基化对其mRNA的表达是否有影响呢？基因RT-PCRanalysisofTβRⅠma:100bpDNAmarker;1,3,5,6:positivemRNAexpression;2,4:negativemRNAexpressionTheexpressionofTβRⅠ,ⅡmRNAinESCCtumorandadjacentnon-canceroustissuesGene本研究结果显示食管鳞癌组织中TβRⅡ的甲基化率高于癌旁组织，其mRNA的表达量也明显低于癌旁组织，但是发生甲基化的癌组织与未发生甲基化的癌组织相比，其mRNA表达虽然降低，但却无统计学差异。结论Thanksforyourattention!头颈部鳞癌、胃癌及胰腺癌细胞株中TβRⅠ基因甲基化与其表达降低有关。Unmethylated目前认为DNA甲基化主要在转录水平抑制基因的表达，TGF-β受体Ⅰ、Ⅱ基因的甲基化对其mRNA的表达是否有影响呢？GeneThanksforyourattention!