湖南化工职业技术学院毕业设计（论文）--专科生毕业论文(设计)邻苯二甲醛消毒剂合成工艺研究摘要邻苯二甲醛(O-phthaleldehyde,简写为OPA),以前是一种重要的医药化工中间体,该中间体在胺类生物碱、荧光计组胺测定及医药检测方面有广泛的应用,而作为消毒剂应用的报道最早见于1994年,Alfa等通过评价OPA作为一种新型的高效消毒剂,与戊二醛相比,不仅具有光谱,高效和低腐蚀性的优点,还具有刺激性小,稳定性好等自身特点.且对耐戊二醛的龟分枝杆菌具有良好的杀灭作用.邻苯二甲醛的合成路线较多,但大多产率较低,成本较高.本课题对邻苯二甲醛的合成路线进行了粗略的讨论.以邻二(一氯甲基)苯为原料,在催化剂存在条件下与无水醋酸钠进行酯化反应,以氯化苯作为溶剂.分离有机相.有机相与水在碱性条件下进行水解反应,分离水相,减压蒸馏得邻苯二甲醇.以邻苯二甲醇为原料通过硝酸氧化得到目的产物邻苯二甲醛.关键词:邻二(一氯甲基)苯；邻苯二甲醇；邻苯二甲醛ABSTRACTOPA(O-phthaleldehyde,abbreviatedasOPA),beforethemedicineisanimportantchemicalintermediate,intermediateinthealkaloidamine,histaminefluorometermedicaltestinganddeterminationofawiderangeofapplications,asApplicationofdisinfectantfoundinthereportasearlyas1994,Alfa,andsoonthroughtheevaluationoftheOPAasanewtypeofhighlyefficientdisinfectant,glutaraldehyde,notonlyhasthespectrum,highefficiencyandlowcorrosiveadvantages,butalsohasasmallirritation,stabilityGood,andsoonitsowncharacteristics.GlutaraldehydeandtheresistanceofMycobacteriumturtlehasagoodeffecttokill.OPA'smoresyntheticroute,butmostofthelowyield,thehigherthecost.OnthesubjectoftheOPA'ssyntheticroutetocarryouttheroughdiscussion.O-to(achloromethyl)benzeneasrawmaterialsinthecatalystundertheconditionsoftheexistenceofwaterandsodiumacetateforesterificationtolindaneasasolvent.Organicphaseseparation.OrganicphaseandwaterinthealkalineconditionsHydrolysis,withwaterseparation,vacuumdistillationwasthesecondo-methyl.OPAtomethanolasrawmaterialshavebeenadoptedbythenitricacidoxidationproductofthepurposeoftheOPA.Keywords:o-(a-methyl)-o-bmethanolOPA目录TOC\o"1-3"\h\z\uHYPERLINK\l"_Toc311107999"摘要PAGEREF_Toc311107999\hIIHYPERLINK\l"_Toc311108000"ABSTRACTPAGEREF_Toc311108000\hIIIHYPERLINK\l"_Toc311108001"1邻苯二甲醛消毒剂的概况PAGEREF_Toc311108001\h1HYPERLINK\l"_Toc311108002"1.1对微生物的杀灭作用PAGEREF_Toc311108002\h1HYPERLINK\l"_Toc311108003"1.2杀菌机理PAGEREF_Toc311108003\h1HYPERLINK\l"_Toc311108004"1.3邻苯二甲醛消毒剂的特点PAGEREF_Toc311108004\h2HY