铜绿假单胞菌感染的流行趋势和治疗进展主要内容PseudomonasAeruginosa(PA)2、致病性定义铜绿假单胞菌3年耐药监测结果分析2007年中国CHINET铜绿假单胞菌耐药性监测Mohnarin2008年度全国细菌耐药监测2009年中国CHINET细菌耐药性监测2009年中国CHINET细菌耐药性监测AntimicrobialResistanceAmongClinicalIsolatesFromTheChineseMeropenemSurveillanceStudy(CMSS),2003–2008（美罗培南敏感性监测(CMSS)报告）革兰阴性杆菌耐药状况研究———2008中国美罗培南敏感性监测(CMSS)报告中国重症监护病房细菌耐药性监测研究中国重症监护病房革兰阴性菌耐药性连续7年监测研究王辉，中华医学杂志，83（5）：385-390.ICU环境及护理人员与发生VAP的关系Nationalsurveillanceofantimicrobialresistanceinpseudomonasaeruginosaisolatesobtainedfromintensivecareunitpatientsfrom1993to2002.Emergenceofextensivelydrug-resistantandpandrug–resistantgram-negativebacilliinEurope感染PA的危险因素治疗疗程PredictorsOf30DayMortalityAmongPatientsWithPseudomonasAeruginosaBloodstreamInfections:ImpactOfDelayedAppropriateAntibioticSelection针对MDR-PA的联合治疗方案针对MDR-PA的联合治疗方案Microbiologicalactivityandclinicalefficacyofacolistinandrifampincombinationinmultidrug-resistantPseudomonasaeruginosainfections.TasciniC,Theclinicalefficacyofthecombinationwastestedinfourpatientswithdifficult-totreatinfections(sepsisorpneumonia)causedbyMDRP.aeruginosa.Allinfectionsweresuccessfullytreated.OurmicrobiologicalandclinicalobservationssuggestthattheadditionofrifampintocolistinmayresultinasynergisticbactericidalcombinationthatmaybeusefulinpatientswithinfectionscausedbyMDRP.aeruginosawhicharedifficulttocure.JChemother.2004Jun;16(3):282-7.Antimicrobialtherapyandcontrolofmultidrug-resistantPseudomonasaeruginosabacteremiainateachinghospitalinTaiwan.LeungCH,METHODS:MDRP.aeruginosaisolateswerecollectedattheMacKayMemorialHospital,Taipei,Taiwan,andantibioticsynergywasinvestigatedbasedonantibioticsusceptibilitytestsusingacombinationofantibiotics.IsolatesofpatientswithMDRP.aeruginosabacteremiawereselectedforgeneticanalysisbypulsed-fieldgelelectrophoresis.RESULTS:Acombinationofceftazidime,amikacin,andsulbactamhadsignificantsynergisticeffectsagainstbloodstreamMDRP.aeruginosaisolatesandwasmorebeneficialclinicallycomparedwithotherantibioticcombinations.ThemajorsourceofMDRP.aeruginosainfectionw