AngewandteChemieDOI:10.1002/anie.200801998DNADetectionUltrasensitiveDNADetectionUsingPhotonicCrystals**MingzhuLi,FangHe,QingLiao,JianLiu,LiangXu,LeiJiang,YanlinSong,*ShuWang,*andDaobenZhuInrecentyears,therehasbeenimmenseinterestintheofthepropagationoflightwithminimallosses.[10]ColloidaldetectionofDNAhybridization,whichisveryimportantforPCsareeconomicalthree-dimensionalPCswithfeaturesizesthediagnosticsofgeneticandpathogenicdiseases.[1]High-ofthewavelengthoflight,whicharemadefromself-sensitivityandhigh-selectivitydetectionisnecessaryforearlyassembledmonodispersedcolloidalspheres.[11]Manyreportsdiseasediagnosisandtreatment.[2]Mostavailablemethodshaverevealedthatspontaneousradiationfromexcitedinvolvemolecular-fluorophore-basedassays,inwhichthemoleculescanbestronglymodifiedbyembeddinglighttargetDNAishybridizedwithaspecificbase-sequenceprobesourcesinthePCs.[12]Vosandco-workershavedemonstratedlabeledwitharadioisotopeorafluorophore.[3]IntheseDNAtheenhancedandangle-dependentemissioninPCs.[13]Thedetectionprocesses,theamplificationstepsareimportanttogroupsofFurumi,[14]Foulger,[15]andVardeny[16]havede-realizetheultimateintermsofsensitivity.TheseamplificationscribeddynamictunablelasersbyusingaPCasanexternalsystemsincludepolymerasechainreaction(PCR)protocolsresonatorcavity.andsignal-amplificationsystems,suchasfluorogenicsub-Inourpreviouswork,weusedPCstoenhancethestrate-activeenzymes,[4]modifiedliposomes,[5]andnanopar-emissiondensityoforganicdyes[17]andtoachievenonlinearticles.[6]However,therelativelycomplexinstrumentandemission.[18]Inallofthereporteddemonstrations,thePCsarespecificreagentsrequiredrestricttheirpracticalapplication.ofgreatpotentialinmodificationofthespontaneousemissionFluorescenceresonanceenergytransfer(FRET)betweenofactiveopticaldevices.[19]ThesuperiorpropertiesofPCsenergy-donorand-acceptorpairsisafeasibleapproachtocreateanewapproachtoamplifyingbiosensorsignalsandimprovethesensitivityandselectivityoftheassay.[7]Inthattherebytodevelopinghi