BioRepair修復牙齒琺瑯質牙膏Prof.NorbertoRoveri諾勃特羅韋裡教授Enamel琺瑯質Toothenameliscomposedmainlyoflarge,prismatic,highlycrystallinehydroxyapatitemicroparticles,togetherwithaverylowproteincomponent(figs.2aand2b).Inadults,enameldoesnotcontainanycellsandisthereforenotcapableofselfregeneration.Anydamageisirreversibleasthereisnobiologicalprocesscapableofrepairingdamagedenamel.Inasimilarway,dentine(figure3)exposedtotheoralenvironmentcannotberegenerated,asnewdentineisdepositedontheinteriorsurfacesofthecrownclosetothepulp,andnotontheoutside.Forthisreason,anyreparativeactionmustbeprovidedbymaterialsorsubstancesthatareextraneoustodentaltissuemetabolism.Thesesubstancesareeithersyntheticorareprecipitatedfromsaliva在成人，琺瑯質不包含任何細胞，因此不能夠自我再生。任何損害不可逆轉的，因為目前沒有生物過程能夠修復受損的琺瑯質。以類似的方式，牙本質（圖3）暴露在口腔環境，不能再生的，新的牙本質沉積在接近牙骨髓的齒冠的內部表層上，而不是在外面。為此，任何修復行動的材料或物質其是與牙齒組織的代謝無關。這些物質要麼是合成的或是從唾液的沉澱中獲得。MICROREPAIR®ThesubstanceusedinBioRepair®Plusistechnologicallyinnovative,inthatbeingintheformofmicroparticlesithasenhancedchemicalreactivity.Microparticlescarryouttheirdentineremineralisingactionbyreleasingtheirconstituentcalciumandphosphorousinsitu.Inthecaseoftheenamel,themicroparticlesactiontakesplaceviatheirabilitytobondtonaturaltissues,thusfillingmicrogapsintheenamel.。Figures5and6:MicroscopicMicrorepair®micro-particlesaggregatesviewedusingTEM(Transmissionelectronmicroscopy)(Scalebar=100μm)(Transmissionelectronmicroscopy)(Scalebar=100μm)Figures7and8:MicroscopicMicrorepair®microparticlesaggregatesviewedusingTEM(Transmissionelectronmicroscopy)(Scalebar=50and20μmrespectively).ActionmechanismTheenhancedreactivityofMICROREPAIR®microparticlesisdueprimarilytothebio-mimeticactionofthesemicroparticles,whichhavethedistinguishingfeatureofpossessingaverysimilarchemicalcompositiontothatofenamelanddentine.TheX-raydiffractionspectrumofMICROREPAIR®microparticles(figure9)showshowthedegreeofcrystallinityofthemicroparticlesishalfwaybetweenthatofenamelanddentine.作用機制增強反應的MICROREPAIR®微粒主要是由於對生物模仿動作，這些具有顯著特徵的微粒與組成琺瑯質和牙本質的化學成分相似