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THEFIRSTAFFLIATEDHOSPITALOFGUANGXIMEDICALUNIVERSITYNeonatalHerpesSimplexInfectionINTRODUCTIONVIROLOGYTRANSMISSIONMaternalviremiaAscendinginfectionUsuallyafterprolongedruptureofmembranes2.Perinatal-HSVinfectionispresentinthegenitaltractofpregnantwomanattimeofdelivery-Mostcommonmode(85%)ofneonatalHSVinfection3.Postnatal-WhenactiveHSVinfectionhasclosecontactwiththenewbornintrauterine5%perinatal85%postnatal10%CLINICALMANIFESTATIONSskinEyes-MouthCNSDiseaseHERPESENCEPHALITIS¼ofHSVdiseaseisinthedisseminatedformPresentinthefirstweekoflifeAffects:liver,lungs,adrenals,CNS,skin,eyes,andmouth,DICDiagnosisofNeonatalHSVInfectionEEGBrainImagingChestRadiographMaydemonstratebilateral,diffusepneumoniaAbdominalUSMaydemonstrateascitesand/orenlargedliverinneonateswithHSVhepatitisandacuteliverfailureTREATMENTINFECTIONCONTROLSTEPSreferences此课件下载可自行编辑修改,供参考!部分内容来源于网络,如有侵权请与我联系删除!