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会计学液体复苏历史回顾常用复苏液体各自特点不同液体复苏效果Humanalbuminadministrationincriticallyillpatients:systematicreviewofrandomisedcontrolledtrialsAComparisonofAlbuminandSalineforFluidResuscitationintheIntensiveCareUnitAComparisonofAlbuminandSalineforFluidResuscitationintheIntensiveCareUnit德国胶体研究权威BoldtJ涉嫌论文造假BoldtJ,HeesenM,WeltersI,etal.Doesthetypeofvolumetherapyinfluenceendothelial-relatedcoagulationinthecriticallyill[J]BrJAnaesth,1995,75(6):740-746.HSA无肯定疗效BoldtJ,HeesenM,MüllerM,etal.Theeffectsofalbuminversushydroxyethylstarchsolutiononcardiorespiratoryandcirculatoryvariablesincriticallyillpatients[J].AnesthAnalg,1996,83(2):254-261.HSA无明显优点BoldtJ,MüellerM,MengesT,etal.Influenceofdifferentvolumetherapyregimensonregulatorsofthecirculationinthecriticallyill[J].BrJAnaesth,1996,77(4):480-487.HSA与HES在创伤患者中相比不能降低循环黏附分子BoldtJ,MüllerM,HeesenM,etal.Influenceofdifferentvolumetherapiesonplateletfunctioninthecriticallyill[J].IntensiveCareMed,1996,22(10):1075-1081.HSA在有凝血障碍风险的患者中推荐用于一线治疗方案BoldtJ,MüllerM,HeesenM,etal.Influenceofdifferentvolumetherapiesandpentoxifyllineinfusiononcirculatingsolubleadhesionmoleculesincriticallyillpatients[J].CritCareMed,1996,24(3):385-391.HSA有减少并发症趋势BoldtJ,MüllerM,MentgesD,etal.Volumetherapyinthecriticallyill:Isthereadifference[J]?IntensiveCareMed,1998,24(1):28-36.HSA无明显优点CHEST研究肾功能影响6S研究2012SSC指南2012欧洲胶体液复苏共识3013-06-11美国FDA对羟乙基淀粉给出了黑框警告FDA给医生提出的建议CRISTAL研究欧盟增加羟乙基淀粉溶液(HES)的禁忌症Albuminversuscrystalloidsolutionsinpatientswiththeacuterespiratorydistresssyndrome:asystematicreviewandmeta-analysisRandomisedtrialsofhumanalbuminforadultswithsepsis:systematicreviewandmeta-analysiswithtrialsequentialanalysisofall-causemortality