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纲要必要的说明问题与背景问题与背景问题与背景问题与背景问题与背景基因调控网络的复杂性LargenetworksComplexcellshasmanycomponentsthatcaninteractincomplexways.Dynamicsprocessesarehardtounderstandbyintuitiveapproachesalone.Geneticregulatorynetworkshavecomplicatedinteractionsfarbeyondcorrelationofgeneexpressionpatterns.Clusteringcannotrevealcausalconnectionsbetweengenes.为什么需要数学建模与仿真?preciseandunambiguousdescriptionofnetworkofinteractionssystematicalderivationofbehavioralpredictions问题与背景问题与背景模型:有向图模型:有向图模型:Baysiannetwork模型:Baysiannetwork模型:Booleannetwork模型:Booleannetwork模型:Booleannetwork模型:Generalizedlogicalnetwork模型:NonlinearODENegativefeedbackGeneencodesaproteininhibitingitsownexpressionimportantforhomeostasis,maintenanceofsystemnearadesiredstateSteadystateanalysisTransientbehaviorsimulation模型:NonlinearODE模型:NonlinearODE模型:Piecewise-linearODE模型:QualitativeDifferentialEquation模型:SpatiallyDistributedModel模型:StochasticModel模型:StochasticModel模型:StochasticModel模型:Rule-basedformalism总结与展望总结与展望参考文献