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.精选范本ResponseEvaluationCriteriainSolidTumors(RECIST)QuickReference:Eligibility·Onlypatientswithmeasurablediseaseatbaselineshouldbeincludedinprotocolswhereobjectivetumorresponseistheprimaryendpoint.Measurabledisease-thepresenceofatleastonemeasurablelesion.Ifthemeasurablediseaseisrestrictedtoasolitarylesion,itsneoplasticnatureshouldbeconfirmedbycytology/histology.Measurablelesions-lesionsthatcanbeaccuratelymeasuredinatleastonedimensionwithlongestdiameter³20mmusingconventionaltechniquesor³10mmwithspiralCTscan.Non-measurablelesions-allotherlesions,includingsmalllesions(longestdiameter<20mmwithconventionaltechniquesor<10mmwithspiralCTscan),i.e.,bonelesions,leptomeningealdisease,ascites,pleural/pericardialeffusion,inflammatorybreastdisease,lymphangitiscutis/pulmonis,cysticlesions,andalsoabdominalmassesthatarenotconfirmedandfollowedbyimagingtechniques;and.·Allmeasurementsshouldbetakenandrecordedinmetricnotation,usingarulerorcalipers.Allbaselineevaluationsshouldbeperformedascloselyaspossibletothebeginningoftreatmentandnevermorethan4weeksbeforethebeginningofthetreatment.·Thesamemethodofassessmentandthesametechniqueshouldbeusedtocharacterizeeachidentifiedandreportedlesionatbaselineandduringfollow-up.·Clinicallesionswillonlybeconsideredmeasurablewhentheyaresuperficial(e.g.,skinnodulesandpalpablelymphnodes).Forthecaseofskinlesions,documentationbycolorphotography,includingarulertoestimatethesizeofthelesion,isrecommended.MethodsofMeasurement–·CTandMRIarethebestcurrentlyavailableandreproduciblemethodstomeasuretargetlesionsselectedforresponseassessment.ConventionalCTandMRIshouldbeperformedwithcutsof10mmorlessinslicethicknesscontiguously.SpiralCTshouldbeperformedusinga5mmcontiguousreconstructionalgorithm.Thisappliestotumorsofthechest,abdomenandpelvis.Headandnecktumorsandthoseofextremitiesusuallyrequirespecificprotocols.·LesionsonchestX-rayareacceptableasmeasurablelesionswhentheyareclearlydefinedandsurroundedbyaeratedlung.However,CTispreferable.·Whentheprimaryendpointofthestudy
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