抗动脉粥样硬化药20141210.ppt
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抗动脉粥样硬化药20141210.ppt

抗动脉粥样硬化药20141210.ppt

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动脉粥样硬化Plasmalipids血脂Cholesterolfreecholesterol(FC)游离胆固醇cholesterolester(CE)胆固醇酯Triglyceride(TG)甘油三脂Phospholipid(PL)磷脂Plasmalipoproteins血浆脂蛋白Apoprotein(apo)载脂蛋白Lipoprotein(apoprotein+lipids)脂蛋白Chylomicron(CM)乳糜微粒Verylowdensitylipoprotein(VLDL)极低密度脂蛋白Lowdensitylipoprotein(LDL)低密度脂蛋白Intermediatedensitylipoprotein(IDL)中间密度脂蛋白Highdensitylipoprotein(HDL)高密度脂蛋白Lipidmetabolisminthebody体内脂质代谢Lipidmetabolisminthebody体内脂质代谢DrugsusedintreatmentofatheroscleosisDrugsusedintreatmentofatheroscleosisDrugsusedintreatmentofatheroscleosisHMGCoAreductaseinhibitorsDrugsusedintreatmentofatheroscleosisActionofHMGCoAreductaseinhibitorsoncholesterolbiosynthesis羟甲基戊二酸单酰辅酶A抑制药对胆固醇合成的作用ActionofHMGCoAreductaseinhibitorsoncholesterolbiosynthesis羟甲基戊二酸单酰辅酶A抑制药对胆固醇合成的作用DrugsusedintreatmentofatheroscleosisActionsofHMGCoAreductaseinhibitorsoncholesterolbiosynthesisDrugsusedintreatmentofatheroscleosis阿伐他汀对脑卒中的一级和二级预防作用辛伐他汀对脑卒中类型和严重度的影响(Meta分析)辛伐他汀对脑卒中随访的结果综合(Meta分析)辛伐他汀辛伐他汀和阿伐他汀对5年随访中脑卒中发生率的影响DrugsusedintreatmentofatheroscleosisActionsofintestinalsterolabsorptioninhibitorsDrugsusedintreatmentofatheroscleosisActionofnicotinicacids烟酸作用示意图DrugsusedintreatmentofatheroscleosisHepaticandperipheraleffectsoffibrates贝特类药物作用环节LPL:lipoproteinlipase;VLDL:very-low-densitylipoproteinsHepaticandperipheraleffectsoffibrates贝特类药物作用环节DrugsusedintreatmentofatheroscleosisDrugsusedintreatmentofatheroscleosisComparisonoflipid-regulatingdrugs